RORB / ROR Beta

RAR-related orphan receptor B

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RORB / ROR Beta (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human RORB / ROR Beta Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66457

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

20 µg/$1,107

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Human RORB / ROR Beta Protein (Recombinant GST, N-terminus) (aa136-224) - LS-G59934

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RORB / ROR Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77761

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

20 µg/$150

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Human RORB / ROR Beta Protein (Recombinant GST) (Full Length) - LS-G30192

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.5 kDa

Price:

10 µg/$479; 25 µg/$670

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RORB / ROR Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100942

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

100 µg/$494

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