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ROR2

receptor tyrosine kinase-like orphan receptor 2

ROR2 is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.

Gene Name: receptor tyrosine kinase-like orphan receptor 2
Family/Subfamily: Protein Kinase , Trk/Ror
Synonyms: ROR2, BDB1, Robinow syndrome, NTRKR2, BDB, Brachydactyly type B
Target Sequences: NM_004560 NP_004551.2 Q01974

Publications (3)

1
Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer. Lu C, Wang X, Zhu H, Feng J, Ni S, Huang J. Oncotarget. 2015 6:24912-21. (IHC; Human) [Full Text Article] [PubMed:26305508] [PMC:PMC4694803] Related Antibodies: LS-C99125.
2
High expression levels of Wnt5a and Ror2 in laryngeal squamous cell carcinoma are associated with poor prognosis. Zhang W, Yan Y, Gu M, Wang X, Zhu H, Zhang S, Wang W. Oncology letters. 2017 August;14:2232-2238. (Human) [Full Text Article] [PubMed:28781662] [PMC:PMC5530173] Related Antibodies: LS-C99125.
3
ROR1 and ROR2 expression in pancreatic cancer. Dongli Liu, George Sharbeen, Phoebe Phillips, Australian Pancreatic Cancer Genome Initiative; Caroline E Ford. BMC cancer. 2021 Nov;21:1199. [Full Text Article] [PubMed:34763666] [PMC:PMC8582180] Related Antibodies: LS-C99126.

☰ Filters
Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
ROR2 (9)
No (9)
6His, C-terminus (1)
DDK (Flag)-His, C-terminus (1)
DDK,C-terminus (1)
GST, N-terminus (1)
His,C-terminus (1)
His-GST (1)
Myc-DDK (Flag) (3)
Human (8)
293T Cells (1)
E. coli (1)
HEK 293 Cells (3)
Mammalian Cells (2)
Sf9 Cells (1)
Wheat Germ Extract (1)
Low endotoxin level (2)
Select
Mammalian Cells
6His, C-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627
ROR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
104.74 kDa
100 µg/$710
ROR2 Protein
Select
Sf9 Cells
DDK,C-terminus
41.3 kDa
20 µg/$677
ROR2 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
44 kDa
20 µg/$1,107
Select
E. coli
His-GST
57.6 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
ROR2 Protein - Purified recombinant protein ROR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
101.3 kDa
20 µg/$1,107
ROR2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ROR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
104.74 kDa
20 µg/$215
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.2 kDa
10 µg/$277; 50 µg/$389
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).