ROCK2

Rho-associated, coiled-coil containing protein kinase 2

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca2+ sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

ROCK2 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human ROCK2 Protein (Recombinant His-T7) (aa904-1140) - LS-G14364

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.1 kDa

Price:

50 µg/$440; 10 µg/$281; 200 µg/$877; 100 µg/$702; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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ROCK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116315

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

160.7 kDa

Price:

100 µg/$710

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Human ROCK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87604

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

160.7 kDa

Price:

20 µg/$215

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Human ROCK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70629

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

160.7 kDa

Price:

20 µg/$1,107

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Human ROCK2 Protein (Recombinant GST, N-terminus) (aa1279-1388) - LS-G61145

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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