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ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | roundabout, axon guidance receptor, homolog 1 (Drosophila) |
| Synonyms: | ROBO1, Deleted in U twenty twenty, H-Robo-1, Roundabout 1, SAX3, DUTT1, Roundabout homolog 1 |
| Target Sequences: | NM_002941 NP_002932.1 Q9Y6N7 |
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