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RNH1
ribonuclease/angiogenin inhibitor 1
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.
| Gene Name: | ribonuclease/angiogenin inhibitor 1 |
| Synonyms: | RNH1, Placental RNase inhibitor, PRI, RAI, Ribonuclease inhibitor, RNH |
| Target Sequences: | NM_002939 NP_002930.2 P13489 |
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