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This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
Gene Name: | ring finger protein 216 |
Family/Subfamily: | Zinc Finger |
Synonyms: | RNF216, TRIAD3, UBCE7IP1, Ring finger protein 216, U7I1, ZIN |
Target Sequences: | NM_207111 NP_996994.1 Q9NWF9 |
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