RNF2 / RING2 / RING1B

ring finger protein 2

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RNF2 / RING2 / RING1B (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human RNF2 / RING2 / RING1B Protein (Recombinant GST, N-terminus) (aa192-290) - LS-G59922

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RNF2 / RING2 / RING1B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71374

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.5 kDa

Price:

20 µg/$1,107

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Human RNF2 / RING2 / RING1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89612

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.5 kDa

Price:

20 µg/$150

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Human RNF2 / RING2 / RING1B Protein (Recombinant GST) (Full Length) - LS-G30183

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.1 kDa

Price:

10 µg/$479; 25 µg/$670

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RNF2 / RING2 / RING1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100993

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.5 kDa

Price:

100 µg/$494

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