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Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Gene Name: | ring finger protein 169 |
Synonyms: | RNF169, KIAA1991, Ring finger protein 169 |
Target Sequences: | NP_001092108.1 Q8NCN4 |
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