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RNF139 / TRC8
ring finger protein 139
E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.
| Gene Name: | ring finger protein 139 |
| Synonyms: | RNF139, HRCA1, RCA1, TRC8, Ring finger protein 139 |
| Target Sequences: | NM_007218 NP_009149.2 Q8WU17 |
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