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RNF125 / TRAC-1

ring finger protein 125, E3 ubiquitin protein ligase

RNF125 is a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.

Gene Name: ring finger protein 125, E3 ubiquitin protein ligase
Synonyms: RNF125, RING finger protein 125, TRAC-1, TRAC1
Target Sequences: NM_017831 NP_060301.2 Q96EQ8

Publications (1)

1
Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia. Juan Tang, Sha Tu, Guoxin Lin, Hui Guo, Chengkai Yan, Qingjun Liu, Ling Huang, Na Tang, Yizhi Xiao, R Marshall Pope, Murugesan V S Rajaram, Amal O Amer, Brian M Ahmer, John S Gunn, Daniel J Wozniak, Lijian Tao, Vincenzo Coppola, Liwen Zhang, Wallace Y Langdon, Jordi B Torrelles, Stanley Lipkowitz, Jian Zhang. The Journal of experimental medicine. 2020 April;217: [Full Text Article] [PubMed:31999304] [PMC:PMC7144527] Related Antibodies: LS-B11326.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
RNF125 / TRAC-1 (4)
No (4)
GST, N-terminus (2)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
RNF125 / TRAC-1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
RNF125 / TRAC-1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
RNF125 / TRAC-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26.3 kDa
20 µg/$150
RNF125 / TRAC-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.3 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).