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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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RNASEL / RNase L

ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

Gene Name: ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Family/Subfamily: Protein Kinase , Provisional Protein Kinase
Synonyms: RNASEL, 2-5A-dependent ribonuclease, 2-5A-dependent RNAase, 2-5A-dependent RNase, HPC1, PRCA1, RNS4, RNase L, Prostate cancer 1, Ribonuclease 4, Ribonuclease L
Target Sequences: NM_021133 NP_066956.1 Q05823

Publications (8)

1
2-5A-dependent RNase molecules dimerize during activation by 2-5A. Dong B, Silverman RH. The Journal of biological chemistry. 1995 270:4133-7. [PubMed:7876164]
2
A bipartite model of 2-5A-dependent RNase L. Dong B, Silverman RH. The Journal of biological chemistry. 1997 272:22236-42. (WB; Human) [PubMed:9268370]
3
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis. Wang L, Zhou A, Vasavada S, Dong B, Nie H, Church JM, Williams BR, Banerjee S, Silverman RH. Clinical cancer research : an official journal of the American Association for Cancer Research. 1995 1:1421-8. [PubMed:9815940]
4
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephan D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikain. Nature genetics. 2002 30:181-4. [PubMed:11799394]
5
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L. Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ. Journal of virology. 2007 81:5561-72. [PubMed:17344297] [PMC:PMC1900262]
6
Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation. Al-Ahmadi W, Al-Ghamdi M, Al-Haj L, Al-Saif M, Khabar KS. Nucleic acids research. 2009 37:3612-24. [PubMed:19359363] [PMC:PMC2699509]
7
Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. Lin RJ, Yu HP, Chang BL, Tang WC, Liao CL, Lin YL. Journal of immunology (Baltimore, Md. : 1950). 2009 183:8035-43. [PubMed:19923450]
8
Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements. Al-Haj L, Blackshear PJ, Khabar KS. Nucleic acids research. 2012 40:7739-52. (WB; Human) [PubMed:22718976] [PMC:PMC3439922]
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Viewing 1-25 of 35 items
RNASEL / RNase L Antibody - Anti-RNASEL / RNase L antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 2E9] (IgG1,k) to Human RNASEL / RNase L
Hamster, Primate, Human
IHC, IHC-P, WB
Unconjugated
100µl   $425.00
RNASEL / RNase L Antibody - Anti-RNASEL / RNase L antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 2E9] (IgG1,k) to Human RNASEL / RNase L
Human, Primate
ELISA, IHC, IHC-P, WB
Biotin Conjugated
100µl   $365.00
RNASEL / RNase L Antibody - Anti-RNASEL / RNase L antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 2E9] (IgG1,k) to Human RNASEL / RNase L
Human, Primate
ELISA, IHC, IHC-P, WB
DY650 Conjugated
100µl   $365.00
RNASEL / RNase L Antibody - Anti-RNASEL / RNase L antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 2E9] (IgG1,k) to Human RNASEL / RNase L
Human, Primate
ELISA, IHC, IHC-P, WB
DY488 Conjugated
100µl   $365.00
RNASEL / RNase L Antibody - Anti-RNASEL / RNase L antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 2E9] (IgG1,k) to Human RNASEL / RNase L
Human, Primate
ELISA, IHC, IHC-P, WB
DY550 Conjugated
100µl   $365.00
RNASEL / RNase L Antibody - Mouse RNase I Antibody western blot of mouse liver tissue lysates (35 ug/lane). The Mouse RNase I antibody detected the Mouse RNase I protein (arrow).
Select
Rabbit Polyclonal to Mouse RNASEL / RNase L
Mouse
WB
Unconjugated
400µl   $325.00
Select
Mouse Monoclonal (IgG1) to Human RNASEL / RNase L
Human
ELISA, ICC, IHC, IHC-P, IP, WB
Unconjugated
100µg   $455.00
Select
Rabbit Polyclonal (IgG) to Human RNASEL / RNase L
Human
ELISA, IHC, WB
Unconjugated
100µg   $355.00
RNASEL / RNase L Antibody - Immunohistochemistry of paraffin-embedded rat kidney tissue.
Select
Rabbit Polyclonal (IgG) to Human RNASEL / RNase L
Mouse, Rat, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $255.00; 100µl   $315.00; 200µl   $425.00
Select
Rabbit Polyclonal (IgG) to Mouse RNASEL / RNase L
Mouse
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Mouse RNASEL / RNase L
Mouse
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse RNASEL / RNase L
Mouse
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse RNASEL / RNase L
Mouse
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse RNASEL / RNase L
Mouse
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse RNASEL / RNase L
Mouse
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse RNASEL / RNase L
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human RNASEL / RNase L
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
RNASEL / RNase L Antibody - Immunohistochemistry of paraffin-embedded human testis tissue using RNASEL Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human RNASEL / RNase L
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RNASEL / RNase L
Human
ELISA, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RNASEL / RNase L
Human
ELISA, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RNASEL / RNase L
Human
ELISA, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
RNASEL / RNase L Antibody - Detection limit for recombinant GST tagged RNASEL is approximately 0.1 ng/ml as a capture antibody.
Select
Mouse Monoclonal [clone 3B4] (IgG1,k) to Human RNASEL / RNase L
Human
ELISA
Unconjugated
100µg   $365.00
Select
Rabbit Polyclonal (IgG) to Human RNASEL / RNase L
Pig, Horse, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $325.00
RNASEL / RNase L Antibody
Select
Rabbit Polyclonal to Human RNASEL / RNase L
Human
WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
RNASEL / RNase L Antibody - Western blot of RNASEL / RNase L antibody.
Select
Rabbit Polyclonal to Human RNASEL / RNase L
Human
WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 500µl   0.5mg/ml   $445.00; 1ml   0.5mg/ml   $530.00

Viewing 1-25 of 35 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).