Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.
|Gene Name:||ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)|
|Family/Subfamily:||Protein Kinase , Provisional Protein Kinase|
|Synonyms:||RNASEL, 2-5A-dependent ribonuclease, 2-5A-dependent RNAase, 2-5A-dependent RNase, HPC1, PRCA1, RNS4, RNase L, Prostate cancer 1, Ribonuclease 4, Ribonuclease L|
|Target Sequences:||NM_021133 NP_066956.1 Q05823|
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