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RNASEH2A

ribonuclease H2, subunit A

RNASEH2A is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.

Gene Name: ribonuclease H2, subunit A
Synonyms: RNASEH2A, AGS4, Aicardi-Goutieres syndrome 4, Ribonuclease HI, large subunit, Ribonuclease HI large subunit, RNase H(35), RNase H2 subunit A, RNase HI large subunit, RNHIA, RNHL, Ribonuclease H2, large subunit, Ribonuclease HI subunit A, RNASEHI, Ribonuclease H2 subunit A, Ribonuclease H2, subunit A
Target Sequences: NM_006397 NP_006388.2 O75792

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Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
RNASEH2A (8)
No (8)
GST (1)
His (1)
His-T7, N-terminus (3)
Myc-DDK (Flag) (3)
Human (5)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
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HEK 293 Cells
Myc-DDK (Flag)
33.2 kDa
100 µg/$494
RNASEH2A Protein - 12.5% SDS-PAGE of human RNASEH2A stained with Coomassie Blue
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Wheat Germ Extract
GST
58.63 kDa
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
33.2 kDa
20 µg/$150
RNASEH2A Protein
Select
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
Select
HEK 293 Cells
Myc-DDK (Flag)
33.2 kDa
20 µg/$1,107
RNASEH2A Protein - Recombinant Ribonuclease H2 Subunit A (RNASEH2A) by SDS-PAGE
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E. coli
His-T7, N-terminus
37.2kDa
10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
RNASEH2A Protein - Recombinant Ribonuclease H2 Subunit A (RNASEH2A) by SDS-PAGE
Select
E. coli
His-T7, N-terminus
37.0kDa
10 µg/$273; 50 µg/$392; 200 µg/$782; 100 µg/$625; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
RNASEH2A Protein - Recombinant Ribonuclease H2 Subunit A (RNASEH2A) by SDS-PAGE
Select
E. coli
His-T7, N-terminus
37.1kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).