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RITA1 / C12orf52

RBPJ interacting and tubulin associated 1

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Gene Name:	RBPJ interacting and tubulin associated 1
Synonyms:	RITA1, C12orf52, RITA
Target Sequences:	NM_032848 CAC32398.1 Q96K30

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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