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20700 44th Avenue W
Lynnwood, WA 98036
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RIPK1 / RIP
receptor (TNFRSF)-interacting serine-threonine kinase 1
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
| Gene Name: | receptor (TNFRSF)-interacting serine-threonine kinase 1 |
| Family/Subfamily: | Protein Kinase , RIP |
| Synonyms: | RIPK1, Cell death protein RIP, Receptor interacting protein, RIP1, RIP, RIP-1, Protein kinase rip, Receptor-interacting protein 1, Rinp |
| Target Sequences: | NM_003804 NP_003795.2 Q13546 |
Publications (1)
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