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RIP1 / RALBP1
ralA binding protein 1
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
| Gene Name: | ralA binding protein 1 |
| Synonyms: | RALBP1, 76 kDa Ral-interacting protein, DNP-SG ATPase, Ral-interacting protein 1, RalA-binding protein 1, RIP1, Rlip76 protein, RIP, RLIP1, RalA binding protein 1, RLIP76 |
| Target Sequences: | NM_006788 NP_006779.1 Q15311 |
Publications (1)
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