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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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RICK / RIP2

receptor-interacting serine-threonine kinase 2

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

Gene Name: receptor-interacting serine-threonine kinase 2
Family/Subfamily: Protein Kinase , RIP
Synonyms: RIPK2, CARD-carrying kinase, CARDIAK, Growth-inhibiting gene 30, Receptor interacting protein 2, Receptor-interacting protein 2, Rick Kinase, RIP2, RICK, RIP-2, Tyrosine-protein kinase RIPK2, CARD3, GIG30
Target Sequences: NM_003821 NP_003812.1 O43353

Viewing 1-25 of 77 items
RICK / RIP2 Antibody - Anti-RIPK2 / RIP2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
RICK / RIP2 Antibody - IHC with RIPK2 antibody on frozen human pancreas.
Select
Mouse Monoclonal [clone 7F5] (IgG1,k) to Human RICK / RIP2
Human
ELISA, IHC, IHC-Fr, WB
Unconjugated
50µg   $495.00
RICK / RIP2 Antibody - RIPK2 monoclonal antibody (M03), clone 3D9 Western blot of RIPK2 expression in HeLa.
Select
Mouse Monoclonal [clone 3D9] (IgG2a,k) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   $365.00
RICK / RIP2 Antibody - Western blot of Phospho-RIP2 (S176) antibody
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
RICK / RIP2 Antibody - Western blot of 293 cell lysate using Phospho-RIPK2(Ser176) Antibody
Select
Rabbit Polyclonal to Human RICK / RIP2
Mouse, Human
WB
Unconjugated
50µg   50µl   1µg/µl   $255.00; 100µg   100µl   1µg/µl   $305.00
RICK / RIP2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using RIPK2 antibody at dilution of 1:100 (200x lens).
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
IF, IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
RICK / RIP2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human RICK / RIP2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
RICK / RIP2 Antibody - RIPK2 monoclonal antibody (M02), clone 6F7 Western blot of RIPK2 expression in HeLa.
Select
Mouse Monoclonal [clone 6F7] (IgG2a,k) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg   $375.00
RICK / RIP2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using RIPK2 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
RICK / RIP2 Antibody - Western blot of RIP2 antibody
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
RICK / RIP2 Antibody
Select
Mouse Monoclonal (IgG1,k) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100µl   $305.00
Select
Rabbit Polyclonal (IgG) to Mouse RICK / RIP2
Mouse, Human
ELISA, ICC, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $530.00
RICK / RIP2 Antibody - Immunocytochemistry of RICK in A431 cells with RICK antibody at 10 µg/ml.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1mg   $375.00
Select
Rabbit Polyclonal to Human RICK / RIP2
Mouse, Human
WB
Unconjugated
50µg   50µl   1µg/µl   $255.00; 100µg   100µl   1µg/µl   $305.00
RICK / RIP2 Antibody - 1:200 staining human lymph node tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
RICK / RIP2 Antibody - Western blot of RICK / RIP2 antibody.
Select
Rabbit Polyclonal to Human RICK / RIP2
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $295.00; 500µl   0.5mg/ml   $425.00; 1ml   0.5mg/ml   $495.00
RICK / RIP2 Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
RICK / RIP2 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using RIPK2 (Phospho-Ser176) antibody.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
RICK / RIP2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using RIPK2 (Ab-176) antibody.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
RICK / RIP2 Antibody - IHC image of RIPK2 Antibody diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
RICK / RIP2 Antibody - Immunohistochemistry of paraffin-embedded human prostate using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Human
ELISA, IHC, IHC-P
Unconjugated
50µl   $285.00; 100µl   $385.00

Viewing 1-25 of 77 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).