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Ribonuclease A / RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
Ribonuclease A / RNASE1 is a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
| Gene Name: | ribonuclease, RNase A family, 1 (pancreatic) |
| Synonyms: | RNASE1, RIB1, Ribonuclease A, Ribonuclease pancreatic, RNase 1, RNase UpI-1, RNS1, Ribonuclease 1, RNase A, HP-RNase, RIB-1 |
| Target Sequences: | NM_002933 NP_002924.1 P07998 |
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