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RHOC
ras homolog family member C
RHOC is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
| Gene Name: | ras homolog family member C |
| Synonyms: | RHOC, ARHC, Rho cDNA clone 9, RhoC GTPase, RHOH9, Small GTP binding protein RhoC, ARH9, H9, Oncogene RHO H9, Ras homolog family member C, RAS-related homolog 9 |
| Target Sequences: | P08134 P08134 |
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