Rho Kinase / ROCK1

Rho-associated, coiled-coil containing protein kinase 1

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.

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Products

ELISA Kits (5)

Type

Custom (3)

Sandwich (2)

Target

Rho Kinase / ROCK1 (5)

Reactivity

Human (1)

Mouse (1)

Rat (2)

Bovine (1)

Format

96-Well Strip Plate (5)

Publications

No (4)

Yes (1)

Sample Type

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Rat Rho Kinase / ROCK1 (Sandwich ELISA) ELISA Kit - LS-F32208

(4.2) Rating

(3) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human Rho Kinase / ROCK1 (Sandwich ELISA) ELISA Kit - LS-F66732

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Bovine Rho Kinase / ROCK1 (Custom) ELISA Kit - LS-F65234

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$783

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Mouse Rho Kinase / ROCK1 (Custom) ELISA Kit - LS-F65340

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

Select

Rat Rho Kinase / ROCK1 (Custom) ELISA Kit - LS-F65995

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

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