RHEB

Ras homolog enriched in brain

Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

RHEB (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (2)

His,N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Insect Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (3)

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Human RHEB Protein (Recombinant GST) (Full Length) - LS-G30174

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

45.98 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RHEB Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67917

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

20 µg/$1,107

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Human RHEB Protein (Recombinant His,N-terminus) (Met1-Cys181) - LS-G137971

Source:

Insect Cells

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.4 kDa

Price:

100 µg/$661

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RHEB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115850

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

100 µg/$494

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Human RHEB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80971

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

20 µg/$150

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Human RHEB Protein (Recombinant) - LS-G3541

Source:

E. coli

Tag:

None

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human RHEB Protein (Recombinant GST, N-terminus) (Met1-Met184) - LS-G140539

Source:

E. coli

Tag:

GST, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.4 kDa

Price:

10 µg/$317; 50 µg/$524

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Human RHEB Protein (Recombinant GST, N-terminus) (Met1-Met184) - LS-G39716

Source:

E. coli

Tag:

GST, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.4kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353

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