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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RHEB

Ras homolog enriched in brain

Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.

Gene Name: Ras homolog enriched in brain
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: RHEB, RHEB2, GTP-binding protein Rheb, Ras homolog enriched in brain
Target Sequences: NM_005614 NP_005605.1 Q15382

Publications (1)

1
Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors of mTORC1 and mTORC2 complexes in ovine uteri and conceptuses. Gao H, Wu G, Spencer TE, Johnson GA, Bazer FW. Biology of reproduction. 2009 81:87-100. (IHC-P; Sheep) [PubMed:19299312] Related Antibodies: LS-B543.

Filtered By: None
Target
RHEB (34)
Reactivity
Human (34)
Mouse (20)
Rat (19)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (5)
Horse (4)
Monkey (4)
Pig (4)
Rabbit (4)
Sheep (5)
Application
IHC (16)
IHC-P (8)
WB (26)
ELISA (12)
IF (1)
IP (1)
Host
rabbit (33)
mouse (1)
Isotype
IgG (31)
IgG1,k (1)
Clonality
monoclonal mc (1)
polyclonal pc (33)
Clone
2C11 (1)
Format
AP Conjugated (2)
APC Conjugated (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (17)
Epitope
aa107-156 (4)
N-Terminus (1)
aa104-134 (1)
aa155-169 (1)
Publications
No (33)
Yes (1)
Showing 1-25 of 34 results

RHEB Antibody IHC-plus™ LS-B543
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Sheep, Rat, Human
IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-RHEB antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of Rheb in Mouse Brain cells with Rheb antibody at 20 ug/ml.
Anti-RHEB antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of Rheb in Mouse Brain cells with Rheb antibody at 20 ug/ml.

RHEB Antibody (clone 2C11) IHC-plus™ LS-B12851
Mouse Monoclonal [clone 2C11] (IgG1,k) to Human RHEB
Mouse, Rat, Human
ELISA IHC IHC-P WB
Unconjugated
50µg 0.41mg/ml  $485.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
RHEB monoclonal antibody (M01), clone 2C11. Western blot of RHEB expression in PC-12.
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
RHEB monoclonal antibody (M01), clone 2C11. Western blot of RHEB expression in PC-12.

RHEB Antibody (aa107-156) IHC-plus™ LS-B11962
Rabbit Polyclonal (IgG) to Human RHEB
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Bat, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg  $485.00
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RHEB antibody western blot of Human fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RHEB antibody western blot of Human fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RHEB Antibody (aa107-156, HRP) LS-C462153
Rabbit Polyclonal (IgG) to Human RHEB
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC IHC-P WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RHEB antibody western blot of Human fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RHEB antibody western blot of Human fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RHEB Antibody (aa107-156, Biotin) LS-C462151
Rabbit Polyclonal (IgG) to Human RHEB
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RHEB antibody western blot of Human fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RHEB antibody western blot of Human fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RHEB Antibody (aa107-156, FITC) LS-C462152
Rabbit Polyclonal (IgG) to Human RHEB
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC IHC-P WB
FITC Conjugated
100µl 1mg/ml  $385.00
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RHEB antibody western blot of Human fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RHEB antibody western blot of Human fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RHEB Antibody LS-C406611
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human liver cancer using RHEB Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human lung cancer using RHEB Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human liver cancer using RHEB Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human lung cancer using RHEB Polyclonal Antibody at dilution of 1:40.

RHEB Antibody LS-C753101
Rabbit Polyclonal (IgG) to Human RHEB
Human
ELISA IHC WB
Unconjugated
100µg  $355.00

RHEB Antibody LS-C679318
Rabbit Polyclonal (IgG) to Human RHEB
Human
ELISA IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer at dilution of 1:100

RHEB Antibody (HRP) LS-C679324
Rabbit Polyclonal (IgG) to Human RHEB
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

RHEB Antibody (Biotin) LS-C679323
Rabbit Polyclonal (IgG) to Human RHEB
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

RHEB Antibody (FITC) LS-C679321
Rabbit Polyclonal (IgG) to Human RHEB
Human
ELISA
FITC Conjugated
50µg  $285.00; 100µg  $385.00

RHEB Antibody (aa104-134) LS-C162588
Rabbit Polyclonal to Human RHEB
Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
RHEB Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.
RHEB Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The RHEB antibody detected the RHEB protein (arrow).
RHEB Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.
RHEB Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The RHEB antibody detected the RHEB protein (arrow).

RHEB Antibody LS-C405294
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human brain using RHEB Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human brain using RHEB Polyclonal Antibody at dilution of 1:20.

RHEB Antibody LS-C401985
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human liver cancer using RHEB Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of Human liver cancer using RHEB Polyclonal Antibody at dilution of 1:25.

RHEB Antibody LS-C192419
Rabbit Polyclonal to Human RHEB
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $385.00
Western blot of RHEB pAb in extracts from mouse brain tissue and Hela cells.
Western blot of RHEB pAb in extracts from mouse brain tissue and Hela cells.

RHEB Antibody LS-C331313
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Human
IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Western blot analysis of extracts of various cell lines, using RHEB antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
Western blot analysis of extracts of various cell lines, using RHEB antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.

RHEB Antibody LS-C405442
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human ovarian cancer using RHEB Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of Human ovarian cancer using RHEB Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of Human ovarian cancer using RHEB Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of Human ovarian cancer using RHEB Polyclonal Antibody at dilution of 1:25.

RHEB Antibody LS-C402134
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human ovarian cancer using RHEB Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human ovarian cancer using RHEB Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human ovarian cancer using RHEB Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human ovarian cancer using RHEB Polyclonal Antibody at dilution of 1:30.

RHEB Antibody LS-C403371
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Rat, Human
ELISA WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Western blot analysis of HeLa and 231 cell, using RHEB Polyclonal Antibody at dilution of 1:350.
Western blot analysis of HeLa and 231 cell, using RHEB Polyclonal Antibody at dilution of 1:350.

RHEB Antibody LS-C194037
Rabbit Polyclonal (IgG) to Human RHEB
Guinea pig, Human
IP WB
Unconjugated
100µg 1ml  $860.00

RHEB Antibody (aa155-169) LS-C75448
Rabbit Polyclonal (IgG) to Human RHEB
Human
WB
Unconjugated
100µl  $590.00

RHEB Antibody (AP) LS-C511077
Rabbit Polyclonal (IgG) to Human RHEB
Human
WB
AP Conjugated
100µl  $785.00

RHEB Antibody (N-Terminus) LS-C19504
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Rat, Human
WB
Unconjugated
100µg 1mg/ml  $365.00
Western blot of Rheb in rat heart cell lysate with Rheb antibody at (A) 2 and (B) 4 ug/ml.
Western blot of Rheb in rat heart cell lysate with Rheb antibody at (A) 2 and (B) 4 ug/ml.

RHEB Antibody (AP) LS-C511079
Rabbit Polyclonal (IgG) to Human RHEB
Mouse, Rat, Human
WB
AP Conjugated
100µl  $680.00
Showing 1-25 of 34 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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