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Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
Gene Name: | regulator of G-protein signaling 20 |
Family/Subfamily: | Regulator of G-protein signalling , not assigned-Regulator of G-protein signalling |
Synonyms: | RGS20, G(z)GAP, Gz-GAP, RGSZ1, ZGAP1 |
Target Sequences: | NM_003702 NP_003693.2 O76081 |
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