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RGS18

regulator of G-protein signaling 18

RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Gene Name: regulator of G-protein signaling 18
Family/Subfamily: Regulator of G-protein signalling , not assigned-Regulator of G-protein signalling
Synonyms: RGS18
Target Sequences: NM_130782 NP_570138.1 Q9NS28

Publications (1)

1
A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF. Blood. 2012 119:1935-45. (IP; Human) [Full Text Article] [PubMed:22210881] [PMC:PMC3293648]

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
RGS18 (4)
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GST (1)
His, N-Terminal (1)
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Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
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Purified (1)
RGS18 Protein - 12.5% SDS-PAGE of human RGS18 stained with Coomassie Blue
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Wheat Germ Extract
GST
51.59 kDa
10 µg/$479; 25 µg/$670
RGS18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
27.4 kDa
20 µg/$150
RGS18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
27.4 kDa
100 µg/$494
RGS18 Protein
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E. coli
His, N-Terminal
27.6 kDa
50 µg/$419
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).