RGS14

regulator of G-protein signaling 14

Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

RGS14 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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RGS14 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115278

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.3 kDa

Price:

100 µg/$494

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Human RGS14 Protein (Recombinant GST) (Full Length) - LS-G32270

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

87.78 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RGS14 Protein (Recombinant GST, N-terminus) (aa468-566) - LS-G61590

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RGS14 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67699

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.3 kDa

Price:

20 µg/$1,107

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Human RGS14 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80516

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.3 kDa

Price:

20 µg/$150

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Human RGS14 Protein (Recombinant His) - LS-G1841

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$544; 10 µg/$292; 50 µg/$411; 250 µg/$954; 500 µg/$1,447

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