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RGS1
regulator of G-protein signaling 1
RGS1 is a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
| Gene Name: | regulator of G-protein signaling 1 |
| Family/Subfamily: | Regulator of G-protein signalling |
| Synonyms: | RGS1, 1R20, B-cell activation protein BL34, BL34, Early response protein 1R20, IER1, IR20 |
| Target Sequences: | NM_002922 NP_002913.3 Q08116 |
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