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RGR

retinal G protein coupled receptor

RGR is a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: retinal G protein coupled receptor
Family/Subfamily: GPCR , Opsin
Synonyms: RGR, RGR-opsin, RP44
Target Sequences: NM_002921 NP_002912.2 P47804

Publications (1)

1
The Visual Cycle in the Inner Retina of Chicken and the Involvement of Retinal G-Protein-Coupled Receptor (RGR). Díaz NM, Morera LP, Tempesti T, Guido ME. Molecular neurobiology. 2017 54:2507-2517. (IHC; Chicken) [Full Text Article] [PubMed:26984602] Related Antibodies: LS-A1043.

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Proteins (5)
Over-Expression Lysate (4)
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RGR (5)
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293T Cells (2)
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RGR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
31.7 kDa
100 µg/$494
RGR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.2 kDa
100 µg/$494
RGR Protein - 12.5% SDS-PAGE of human RGR stained with Coomassie Blue
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Wheat Germ Extract
GST
58.19 kDa
10 µg/$479; 25 µg/$670
RGR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
31.7 kDa
20 µg/$150
RGR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.2 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).