RGMA

repulsive guidance molecule family member a

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

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Products

ELISA Kits (4)

Type

Custom (1)

Sandwich (3)

Target

RGMA (4)

Reactivity

Human (2)

Mouse (1)

Chicken (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (3)

Publications

No (4)

Sample Type

Cell Culture Supernatants (1)

Plasma (3)

Serum (3)

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Human RGMA (Sandwich ELISA) ELISA Kit - LS-F19853

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse RGMA (Sandwich ELISA) ELISA Kit - LS-F19854

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$685

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Human RGMA (Sandwich ELISA) ELISA Kit - LS-F50346

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

12.29 - 3000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$672

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Chicken RGMA (Custom ELISA) ELISA Kit - LS-F19855

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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