RFX5

regulatory factor X, 5 (influences HLA class II expression)

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

RFX5 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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RFX5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123183

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.1 kDa

Price:

100 µg/$494

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Human RFX5 Protein (Recombinant His, N-Terminal) - LS-G145276

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

23.1 kDa

Price:

50 µg/$419

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RFX5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120999

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.1 kDa

Price:

100 µg/$710

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Human RFX5 Protein (Recombinant GST) (Full Length) - LS-G30160

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

91.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RFX5 Protein (Recombinant GST, N-terminus) (aa516-616) - LS-G59907

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RFX5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74785

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.1 kDa

Price:

20 µg/$150

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Human RFX5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74787

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.1 kDa

Price:

20 µg/$215

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Human RFX5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65077

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.1 kDa

Price:

20 µg/$1,107

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