RFX / RFX1 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
|Gene Name:||regulatory factor X, 1 (influences HLA class II expression)|
|Synonyms:||RFX1, Enhancer factor C, EFC, Regulatory factor X 1, RFX, Transcription factor RFX1, EF-C|
|Target Sequences:||NM_002918 NP_002909.4 P22670|
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