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RFC5
replication factor C (activator 1) 5, 36.5kDa
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9.
| Gene Name: | replication factor C (activator 1) 5, 36.5kDa |
| Synonyms: | RFC5, Activator 1 subunit 5, A1 36 kDa subunit, Activator 1 36 kDa subunit, RF-C 36 kDa subunit, RFC, 36.5 kD subunit, RFC36, Replication factor C subunit 5 |
| Target Sequences: | NM_007370 NP_031396.1 P40937 |
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