RET

ret proto-oncogene

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.

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Products

Proteins (12)

Type

Over-Expression Lysate (4)

Recombinant (8)

Target

RET (12)

Application

SDS-PAGE (1)

Publications

No (12)

Tag

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (2)

GST (1)

GST, N-terminus (1)

His (1)

His,N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (4)

Species

Human (10)

Source

293T Cells (2)

Baculovirus (1)

HEK 293 Cells (4)

Human Cells (1)

Sf9 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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Human RET Protein (Recombinant His,N-terminus) (Met1-Arg635) - LS-G47754

Source:

HEK 293 Cells

Tag:

His,N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human RET consists of 618 amino acids and has a calculated molecular mass of 69.1 kDa. The apparent molecular mass of the protein is approximately 110-120 kDa in SDS-PAGE under reducing conditions.

Price:

50 µg/$441; 1 mg/$2,003

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RET Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110853

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.1 kDa

Price:

100 µg/$710

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RET Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111106

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.7 kDa

Price:

100 µg/$494

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Human RET Protein (Recombinant DDK,C-terminus) - LS-G142380

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

35.3 kDa

Price:

20 µg/$677

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Human RET Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142232

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

70.5 kDa

Price:

20 µg/$1,107

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Human RET Protein (Recombinant DDK,C-terminus) - LS-G142413

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

67.78 kDa

Price:

20 µg/$677

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Human RET Protein (Recombinant GST) (Full Length) - LS-G30151

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.48 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RET Protein (Recombinant GST, N-terminus) (aa361-458) - LS-G59898

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RET Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76373

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.7 kDa

Price:

20 µg/$150

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Human RET Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76374

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.1 kDa

Price:

20 µg/$215

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Human RET Protein (Recombinant His-GST) (His658-Ser1114) - LS-G97826

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

76.7 kDa

Price:

50 µg/$707

Select

Human RET Protein (Recombinant His) (Met1-Arg635) - LS-G97830

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

69.1 kDa

Price:

50 µg/$721

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