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Unfortunately, the antibody LS-C248651 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



RET Antibodies

ret proto-oncogene

The recombination of RET tyrosine kinase with several genes, such as GOLGA5 and the H4 gene, results in a consitutively active oncogenic protein. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.

Gene Name: ret proto-oncogene
Family/Subfamily: Protein Kinase , Cadherin
Synonyms: RET Antibody, Cadherin family member 12 Antibody, CDHF12 Antibody, C-ret Antibody, Hirschsprung disease 1 Antibody, HSCR1 Antibody, Hydroxyaryl-protein kinase Antibody, Oncogene ret Antibody, Proto-oncogene c-Ret Antibody, RET-ELE1 Antibody, RET51 Antibody, Ret proto-oncogene Antibody, RET transforming sequence Antibody, RET43 Antibody, Men2-ret Antibody, MEN2B Antibody, MTC1 Antibody, Receptor tyrosine kinase Antibody, CDHR16 Antibody, MEN2A Antibody, PTC Antibody, RET9 Antibody
Target Sequences: NM_020630 NP_065681.1 P07949
 RET Feature Table
Featured Image

Featured RET Antibody

LS-B6328 is a mouse monoclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.


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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
RET Mouse IgG1 Monoclonal 8D10C9 Unconjugated Human IHC-P, WB, ELISA aa896-1063 No Primary
Anti-RET Antibody (aa896-1063, clone 8D10C9) IHC-plus™ LS-B6328
IHC Image
WB Image
Mouse Monoclonal [clone 8D10C9] (IgG1) to Human RET
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
RET Rabbit Polyclonal Unconjugated Human IHC-P, WB C-Terminus No Primary
Anti-RET Antibody (C-Terminus) IHC-plus™ LS-B6923
IHC Image
IHC Image
Rabbit Polyclonal to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Rabbit Polyclonal Unconjugated Human WB, Flo N-Terminus No Primary
Anti-RET Antibody (N-Terminus) LS-C99120
IHC Image
Flo Image
Rabbit Polyclonal to Human RET
Human
Western blot, Flow Cytometry
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB N-Terminus No Primary
Anti-RET Antibody (N-Terminus) IHC-plus™ LS-B6584
IHC Image
IHC Image
Rabbit Polyclonal (IgG) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG2a,k Monoclonal 1A5 Unconjugated Human IHC-P, WB, ELISA No Primary
Anti-RET Antibody (clone 1A5) IHC-plus™ LS-B10954
IHC Image
ELISA Image
Mouse Monoclonal [clone 1A5] (IgG2a,k) to Human RET
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
RET Mouse IgM,k Monoclonal Unconjugated Human IHC-P, IF, WB No Primary
Anti-RET Antibody LS-C162547
IHC Image
IHC Image
Mouse Monoclonal (IgM,k) to Human RET
Human
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 20B8 Unconjugated Human IHC-P, WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 20B8) LS-C339769
IHC Image
IHC Image
Mouse Monoclonal [clone 20B8] (IgG1) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 5F2 Unconjugated Human IHC-P, WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 5F2) LS-C339755
IHC Image
IHC Image
Mouse Monoclonal [clone 5F2] (IgG1) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 4H3 Unconjugated Human IHC-P, WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 4H3) LS-C339708
IHC Image
IHC Image
Mouse Monoclonal [clone 4H3] (IgG1) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 21H5 Unconjugated Human IHC-P, WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 21H5) LS-C339799
IHC Image
IHC Image
Mouse Monoclonal [clone 21H5] (IgG1) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 1G1 Unconjugated Human IHC-P, WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 1G1) LS-C339712
IHC Image
IHC Image
Mouse Monoclonal [clone 1G1] (IgG1) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG2b Monoclonal 5C7 Unconjugated Human IHC-P, WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 5C7) LS-C339694
IHC Image
IHC Image
Mouse Monoclonal [clone 5C7] (IgG2b) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 21H4 Unconjugated Human IHC-P, WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 21H4) LS-C339731
IHC Image
IHC Image
Mouse Monoclonal [clone 21H4] (IgG1) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 5C5 Unconjugated Human IHC-P, WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 5C5) LS-C339719
IHC Image
IHC Image
Mouse Monoclonal [clone 5C5] (IgG1) to Human RET
Human
IHC - Paraffin, Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 5D4 Unconjugated Human IHC-P aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 5D4) LS-C339709
IHC Image
IHC Image
Mouse Monoclonal [clone 5D4] (IgG1) to Human RET
Human
IHC - Paraffin
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB, ELISA aa881-930 No Primary
Anti-RET Antibody (aa881-930) LS-C199525
WB Image
Rabbit Polyclonal (IgG) to Human RET
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot, ELISA
Unconjugated
RET Rabbit Monoclonal EPR2871 Unconjugated Human, Mouse, Rat IHC-P, ICC, WB, IP, Flo C-Terminus No Primary
Anti-RET Antibody (C-Terminus, clone EPR2871) LS-C138246
IHC Image
WB Image
Rabbit Monoclonal [clone EPR2871] to Human RET
Human, Mouse, Rat
IHC - Paraffin, ICC, Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated
RET Rabbit IgG Polyclonal 15B Unconjugated Human, Mouse, Rat IHC-P, WB, ELISA Internal No Primary
Anti-RET Antibody (Internal, clone 15B) LS-C191742
IHC Image
WB Image
Rabbit Polyclonal [clone 15B] (IgG) to Human RET
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, ELISA pTyr905 No Primary
Anti-RET Antibody (phospho-Tyr905) LS-C291164
Rabbit Polyclonal (IgG) to Human RET
Human, Mouse, Rat
IHC, Immunofluorescence, ELISA
Unconjugated
RET Mouse IgG1 Monoclonal RET01 Unconjugated Human IHC-P C-Terminus No Primary
Anti-RET Antibody (C-Terminus, clone RET01) LS-C95523
IHC Image
Mouse Monoclonal [clone RET01] (IgG1) to Human RET
Human
IHC - Paraffin
Unconjugated
RET Mouse IgG1 Monoclonal 3F8 Unconjugated Human IHC-P No Primary
Anti-RET Antibody (clone 3F8) LS-C87551
IHC Image
Mouse Monoclonal [clone 3F8] (IgG1) to Human RET
Human
IHC - Paraffin
Unconjugated
RET Mouse IgG1 Monoclonal Unconjugated Human IHC-P, WB, ELISA aa896-1063 No Primary
Anti-RET Antibody (aa896-1063) LS-C41514
WB Image
Mouse Monoclonal (IgG1) to Human RET
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
RET Mouse IgG1 Monoclonal Unconjugated Human IHC-P, WB, ELISA aa896-1063 No Primary
Anti-RET Antibody (aa896-1063) LS-C41512
WB Image
Mouse Monoclonal (IgG1) to Human RET
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
RET Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB pTyr1062 No Primary
Anti-RET Antibody (phospho-Tyr1062) LS-C192207
Rabbit Polyclonal to Human RET
Human, Mouse, Rat
IHC, Western blot
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB C-Terminus No Primary
Anti-RET Antibody (C-Terminus) LS-C193954
Rabbit Polyclonal (IgG) to Human RET
Human, Mouse, Rat
IHC, Western blot
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human IHC, WB, Flo, ELISA aa21-51 No Primary
Anti-RET Antibody (aa21-51) LS-C324625
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, Flow Cytometry, ELISA
Unconjugated
RET Rabbit IgG Polyclonal FITC Conjugated Human IHC, WB, Flo, ELISA aa21-51 No Primary
Anti-RET Antibody (aa21-51, FITC) LS-C239935
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, Flow Cytometry, ELISA
FITC Conjugated
RET Rabbit IgG Polyclonal AP Conjugated Human IHC, WB, ELISA aa1020-1050 No Primary
Anti-RET Antibody (aa1020-1050, AP) LS-C239917
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
AP Conjugated
RET Rabbit IgG Polyclonal APC Conjugated Human IHC, WB, ELISA aa159-189 No Primary
Anti-RET Antibody (aa159-189, APC) LS-C239927
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
APC Conjugated
RET Rabbit IgG Polyclonal AP Conjugated Human IHC, WB, ELISA aa159-189 No Primary
Anti-RET Antibody (aa159-189, AP) LS-C239926
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
AP Conjugated
RET Rabbit IgG Polyclonal APC Conjugated Human IHC, WB, ELISA aa1020-1050 No Primary
Anti-RET Antibody (aa1020-1050, APC) LS-C239918
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
APC Conjugated
RET Rabbit IgG Polyclonal PE Conjugated Human IHC, WB, ELISA aa1020-1050 No Primary
Anti-RET Antibody (aa1020-1050, PE) LS-C239921
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
PE Conjugated
RET Rabbit IgG Polyclonal FITC Conjugated Human IHC, WB, ELISA aa1020-1050 No Primary
Anti-RET Antibody (aa1020-1050, FITC) LS-C239920
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
FITC Conjugated
RET Rabbit IgG Polyclonal Biotin Conjugated Human IHC, WB, ELISA aa1020-1050 No Primary
Anti-RET Antibody (aa1020-1050, Biotin) LS-C239919
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
Biotin Conjugated
RET Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human IHC, WB, ELISA aa159-189 No Primary
Anti-RET Antibody (aa159-189, Azide-free, HRP) LS-C248650
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
HRP Conjugated, Azide-free
RET Rabbit IgG Polyclonal Unconjugated Human IHC, WB, ELISA aa1020-1050 No Primary
Anti-RET Antibody (aa1020-1050) LS-C324614
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human IHC, WB, ELISA aa159-189 No Primary
Anti-RET Antibody (aa159-189) LS-C324619
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
Unconjugated
RET Rabbit IgG Polyclonal Biotin Conjugated Human IHC, WB, ELISA aa159-189 No Primary
Anti-RET Antibody (aa159-189, Biotin) LS-C239929
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
Biotin Conjugated
RET Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human IHC, WB, ELISA aa1020-1050 No Primary
Anti-RET Antibody (aa1020-1050, Azide-free, HRP) LS-C248648
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
HRP Conjugated, Azide-free
RET Rabbit IgG Polyclonal PE Conjugated Human IHC, WB, ELISA aa159-189 No Primary
Anti-RET Antibody (aa159-189, PE) LS-C239931
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
PE Conjugated
RET Rabbit IgG Polyclonal FITC Conjugated Human IHC, WB, ELISA aa159-189 No Primary
Anti-RET Antibody (aa159-189, FITC) LS-C239930
Rabbit Polyclonal (IgG) to Human RET
Human
IHC, Western blot, ELISA
FITC Conjugated
RET Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA aa1041-1090 No Primary
Anti-RET Antibody (aa1041-1090) LS-C118241
WB Image
Rabbit Polyclonal (IgG) to Human RET
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA pTyr1015 No Primary
Anti-RET Antibody (phospho-Tyr1015) LS-C199526
WB Image
Rabbit Polyclonal (IgG) to Human RET
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
RET Mouse IgG1 Monoclonal 6E4C4 Unconjugated Human WB, ELISA aa896-1063 No Primary
Anti-RET Antibody (aa896-1063, clone 6E4C4) LS-C82173
WB Image
Mouse Monoclonal [clone 6E4C4] (IgG1) to Human RET
Human
Western blot, ELISA
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA pTyr1062 No Primary
Anti-RET Antibody (phospho-Tyr1062) LS-C117472
WB Image
Rabbit Polyclonal (IgG) to Human RET
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
RET Rabbit Polyclonal Unconjugated Human WB C-Terminus No Primary
Anti-RET Antibody (C-Terminus) LS-C99119
WB Image
Rabbit Polyclonal to Human RET
Human
Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 2G6 Unconjugated Human WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 2G6) LS-C339693
WB Image
Mouse Monoclonal [clone 2G6] (IgG1) to Human RET
Human
Western blot
Unconjugated
RET Mouse IgG1 Monoclonal 2B3 Unconjugated Human WB aa713-1017 No Primary
Anti-RET Antibody (aa713-1017, clone 2B3) LS-C339696
WB Image
Mouse Monoclonal [clone 2B3] (IgG1) to Human RET
Human
Western blot
Unconjugated
RET Rabbit Polyclonal Unconjugated Human, Monkey, Bat, Bovine, Pig, Rabbit, Chicken, Xenopus, Zebrafish WB aa867-916 No Primary
Anti-RET Antibody (aa867-916) LS-C151180
WB Image
Rabbit Polyclonal to Human RET
Human, Monkey, Bat, Bovine, Pig, Rabbit, Chicken, Xenopus, Zebrafish
Western blot
Unconjugated
RET Rabbit Polyclonal Unconjugated Human WB No Primary
Anti-RET Antibody LS-C155981
WB Image
Rabbit Polyclonal to Human RET
Human
Western blot
Unconjugated
RET Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB Trp1056 No Primary
Anti-RET Antibody (Trp1056) LS-C177671
WB Image
Rabbit Polyclonal to Human RET
Human, Mouse, Rat
Western blot
Unconjugated
RET Rabbit IgG Polyclonal Biotin Conjugated WB, ELISA No Primary
Anti-RET Antibody (Biotin) LS-C305702
Rabbit Polyclonal (IgG)
Western blot, ELISA
Biotin Conjugated
RET Rabbit IgG Polyclonal Unconjugated WB, ELISA No Primary
Anti-RET Antibody LS-C298762
Rabbit Polyclonal (IgG)
Western blot, ELISA
Unconjugated
RET Rabbit IgG Polyclonal Unconjugated Human WB, IP No Primary
Anti-RET Antibody LS-C193953
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, Immunoprecipitation
Unconjugated
RET Rabbit Polyclonal Unconjugated Human ELISA aa1078-1093 No Primary
Anti-RET Antibody (aa1078-1093) LS-C3185
Rabbit Polyclonal to Human RET
Human
ELISA
Unconjugated
RET Goat Polyclonal AP Conjugated Mouse ICC Extracellular Domain No Primary
Anti-RET Antibody (Extracellular Domain, AP) LS-C87108
Goat Polyclonal to Mouse RET
Mouse
ICC
AP Conjugated
RET Rabbit IgG Polyclonal FITC Conjugated WB No Primary
Anti-RET Antibody (FITC) LS-C305741
Rabbit Polyclonal (IgG)
Western blot
FITC Conjugated
RET Rabbit Polyclonal Unconjugated Human, Monkey ELISA aa166-182 No Primary
Anti-RET Antibody (aa166-182) LS-C3184
Rabbit Polyclonal to Human RET
Human, Monkey
ELISA
Unconjugated
RET Mouse IgG1 Monoclonal Unconjugated Human, Mouse WB, Flo, ELISA No Primary
Anti-RET Antibody LS-C75422
Flo Image
Mouse Monoclonal (IgG1) to Human RET
Human, Mouse
Western blot, Flow Cytometry, ELISA
Unconjugated
RET Rabbit IgG Polyclonal Biotin Conjugated Human WB, ELISA aa1071-1100 No Primary
Anti-RET Antibody (aa1071-1100, Biotin) LS-C239924
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, ELISA
Biotin Conjugated
RET Rabbit IgG Polyclonal APC Conjugated Human WB, ELISA aa1071-1100 No Primary
Anti-RET Antibody (aa1071-1100, APC) LS-C239923
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, ELISA
APC Conjugated
RET Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa1071-1100 No Primary
Anti-RET Antibody (aa1071-1100) LS-C324616
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, ELISA
Unconjugated
RET Rabbit IgG Polyclonal FITC Conjugated Human WB, ELISA aa1071-1100 No Primary
Anti-RET Antibody (aa1071-1100, FITC) LS-C239925
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, ELISA
FITC Conjugated
RET Rabbit IgG Polyclonal PE Conjugated Human WB, ELISA aa1071-1100 No Primary
Anti-RET Antibody (aa1071-1100, PE) LS-C239928
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, ELISA
PE Conjugated
RET Rabbit IgG Polyclonal Unconjugated Human WB, IP pTyr905 No Primary
Anti-RET Antibody (phospho-Tyr905) LS-C38815
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, Immunoprecipitation
Unconjugated
RET Rabbit IgG Polyclonal AP Conjugated Human WB, ELISA aa1071-1100 No Primary
Anti-RET Antibody (aa1071-1100, AP) LS-C239922
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, ELISA
AP Conjugated
RET Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human WB, ELISA aa1071-1100 No Primary
Anti-RET Antibody (aa1071-1100, Azide-free, HRP) LS-C248649
Rabbit Polyclonal (IgG) to Human RET
Human
Western blot, ELISA
HRP Conjugated, Azide-free
RET Mouse IgG1 Monoclonal PE Conjugated Human Flo No Primary
Anti-RET Antibody (PE) LS-C75425
Mouse Monoclonal (IgG1) to Human RET
Human
Flow Cytometry
PE Conjugated
RET Mouse IgG1 Monoclonal CF Conjugated Human Flo No Primary
Anti-RET Antibody (CF) LS-C75424
Mouse Monoclonal (IgG1) to Human RET
Human
Flow Cytometry
CF Conjugated
RET Mouse IgG1 Monoclonal APC Conjugated Human Flo No Primary
Anti-RET Antibody (APC) LS-C75423
Mouse Monoclonal (IgG1) to Human RET
Human
Flow Cytometry
APC Conjugated
Target Corresponding Antibodies
RET
RET Antibody Blocking Peptide - LS-E9173
LS-E9173
RET
LS-B6584
RET
RET Antibody Blocking Peptide - LS-E9174
LS-E9174
RET
LS-C99119
RET
RET Antibody Blocking Peptide - LS-E9175
LS-E9175
RET
LS-C99120
RET
RET Antibody Blocking Peptide - LS-E9176
LS-E9176
RET
LS-B6923
RET
RET Antibody Blocking Peptide - LS-E10752
LS-E10752
RET
LS-C151180
Type Target Reactivity Sample Type
Cell-Based Phosphorylation RET Mouse, Human, Rat Adherent Cell Cultures
Mouse/Human/Rat Phospho-RET (Tyr1015) Cell-Based ELISA Kit - LS-F1218
Cell-Based Phosphorylation
Mouse, Human, Rat
96-Well Microplate with Colorimetric - 450nm detection type
Adherent Cell Cultures
Cell-Based Phosphorylation RET Mouse, Human, Rat Adherent Cell Cultures
Mouse/Human/Rat Phospho-RET (Tyr1062) Cell-Based ELISA Kit - LS-F1615
Cell-Based Phosphorylation
Mouse, Human, Rat
96-Well Microplate with Colorimetric - 450nm detection type
Adherent Cell Cultures
Cell-Based RET Mouse, Human, Rat Adherent Cell Cultures
Mouse/Human/Rat RET Cell-Based ELISA Kit - LS-F2285
Cell-Based
Mouse, Human, Rat
96-Well Microplate with Colorimetric - 450nm detection type
Adherent Cell Cultures
EIA Competition RET Plasma, Serum
RET EIA Kit - LS-F6126
EIA Competition
96-Well Strip Plate with Colorimetric - 450nm detection type
Plasma, Serum

RET Feature Table


Feature Type Location Details
catalytic activity 1 - 1114 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Disease 1 - 1114 Chromosomal aberrations involving RET are a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene; inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene; translocation t(10;14)(q11;q32) with GOLGA5 generates the RET/GOLGA5 (PTC5) oncogene; translocation t(8;10)(p21.3;q11.2) with PCM1 generates the PCM1/RET fusion; translocation t(6;10)(p21.3;q11.2) with RFP generates the Delta RFP/RET oncogene; translocation t(1;10)(p13;q11) with TRIM33 generates the TRIM33/RET (PTC7) oncogene; translocation t(7;10)(q32;q11) with TIF1 generates the TIF1/RET (PTC6) oncogene. The PTC5 oncogene has been found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl.
Disease 1 - 1114 Defects in RET are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
Disease 1 - 1114 Defects in RET are a cause of Hirschsprung disease (HSCR) [MIM:142623]. HSCR is a genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Occasionally, MEN2A or FMTC occur in association with HSCR.
Disease 1 - 1114 Defects in RET are a cause of pheochromocytoma [MIM:171300]. The pheochromocytomas are catecholamine-producing, chromaffin tumors that arise in the adrenal medulla in 90% of cases. In the remaining 10% of cases, they develop in extra- adrenal sympathetic ganglia and may be referred to as "paraganglioma." Pheochromocytoma usually presents with hypertension. Approximately 10% of pheochromocytoma is hereditary. The genetic basis for most cases of non-syndromic familial pheochromocytoma is unknown.
Disease 1 - 1114 Defects in RET are a cause of renal adysplasia [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.
Disease 1 - 1114 Defects in RET are the cause of medullary thyroid carcinoma (MTC) [MIM:155240]. MTC is a rare tumor derived from the C cells of the thyroid. Three hereditary forms are known, that are transmitted in an autosomal dominant fashion: (a) multiple neoplasia type 2A (MEN2A), (b) multiple neoplasia type IIB (MEN2B) and (c) familial MTC (FMTC), which occurs in 25-30% of MTC cases and where MTC is the only clinical manifestation.
Disease 1 - 1114 Defects in RET are the cause of multiple neoplasia type 2A (MEN2A) [MIM:171400]; also known as multiple neoplasia type 2 (MEN2). MEN2A is the most frequent form of medullary thyroid cancer (MTC). It is an inherited cancer syndrome characterized by MTC, phaeochromocytoma and/or hyperparathyroidism.
Disease 1 - 1114 Defects in RET are the cause of multiple neoplasia type 2B (MEN2B) [MIM:162300]. MEN2B is an uncommon inherited cancer syndrome characterized by predisposition to MTC and phaeochromocytoma which is associated with marfanoid habitus, mucosal neuromas, skeletal and ophtalmic abnormalities, and ganglioneuromas of the intestine tract. Then the disease progresses rapidly with the development of metastatic MTC and a pheochromocytome in 50% of cases.
Disease 1 - 1114 Defects in RET may be a cause of colorectal cancer (CRC) [MIM:114500].
Function 1 - 1114 Probable receptor with tyrosine-protein kinase activity; important for development.
polymorphism 1 - 1114 The Cys-982 polymorphism may be associated with an increased risk for developing Hirschsprung disease.
ptm 1 - 1114 Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation.
sequence caution 1 - 1114 Sequence=AAA36524.1; Type=Erroneous initiation; Sequence=CAA33787.1; Type=Erroneous initiation; Sequence=CAC14882.1; Type=Erroneous initiation;
Similarity 1 - 1114 Belongs to the protein kinase superfamily. Tyr protein kinase family.
Similarity 1 - 1114 Contains 1 cadherin domain.
Similarity 1 - 1114 Contains 1 protein kinase domain.
Subcellular Location 1 - 1114 Membrane; Single-pass type I membrane protein.
Subunit 1 - 1114 Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5 (By similarity).
web resource 1 - 1114 Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RETID76.html";
web resource 1 - 1114 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RET";
web resource 1 - 1114 Name=MEN2 RET database; URL="http://www.arup.utah.edu/database/MEN2/MEN2_welcome.php";
arrayexpress 1 - 1114 P07949
bgee 1 - 1114 P07949
brenda 1 - 1114 2.7.10.1
cleanex 1 - 1114 HS_RET
ctd 1 - 1114 5979
doi 1 - 1114 10
drugbank 1 - 1114 DB01268
eggnog 1 - 1114 prNOG12621
embl 1 - 1114 AJ297349
embl 1 - 1114 M16029
embl 1 - 1114 M31213
embl 1 - 1114 X12949
embl 1 - 1114 X15262
embl 1 - 1114 X15786
ensembl 1 - 1114 ENST00000355710
gene3d 1 - 1114 G3DSA:2.60.40.60
genecards 1 - 1114 GC10P043572
geneid 1 - 1114 5979
genevestigator 1 - 1114 P07949
germonline 1 - 1114 ENSG00000165731
go 1 - 1114 GO:0004714
go 1 - 1114 GO:0005509
go 1 - 1114 GO:0005524
go 1 - 1114 GO:0006468
go 1 - 1114 GO:0007156
go 1 - 1114 GO:0007497
go 1 - 1114 GO:0016021
hgnc 1 - 1114 HGNC:9967
hogenom 1 - 1114 HBG444015
hovergen 1 - 1114 HBG002609
hpa 1 - 1114 CAB002581
hpa 1 - 1114 CAB018342
hpa 1 - 1114 HPA008356
inparanoid 1 - 1114 P07949
interpro 1 - 1114 IPR000719
interpro 1 - 1114 IPR001245
interpro 1 - 1114 IPR002126
interpro 1 - 1114 IPR008266
interpro 1 - 1114 IPR011009
interpro 1 - 1114 IPR015777
interpro 1 - 1114 IPR015919
interpro 1 - 1114 IPR016249
interpro 1 - 1114 IPR017441
interpro 1 - 1114 IPR020635
interpro 1 - 1114 IPR020685
ipi 1 - 1114 IPI00013983
kegg 1 - 1114 hsa:5979
medline 1 - 1114 20081080
medline 1 - 1114 20087238
medline 1 - 1114 20284753
medline 1 - 1114 20438683
medline 1 - 1114 20513733
medline 1 - 1114 21550045
medline 1 - 1114 22080693
medline 1 - 1114 22672949
medline 1 - 1114 22982299
medline 1 - 1114 87257826
medline 1 - 1114 89282212
medline 1 - 1114 89282215
medline 1 - 1114 90150283
medline 1 - 1114 90272230
medline 1 - 1114 93275414
medline 1 - 1114 93372843
medline 1 - 1114 94151373
medline 1 - 1114 94159102
medline 1 - 1114 94159103
medline 1 - 1114 94159104
medline 1 - 1114 94272459
medline 1 - 1114 94348513
medline 1 - 1114 95148221
medline 1 - 1114 95152521
medline 1 - 1114 95163936
medline 1 - 1114 95179108
medline 1 - 1114 95187155
medline 1 - 1114 95219414
medline 1 - 1114 95303511
medline 1 - 1114 95360000
medline 1 - 1114 96090258
medline 1 - 1114 96121602
medline 1 - 1114 96140742
medline 1 - 1114 96210855
medline 1 - 1114 96223053
medline 1 - 1114 96400962
medline 1 - 1114 97196781
medline 1 - 1114 97220587
medline 1 - 1114 97245887
medline 1 - 1114 97247905
medline 1 - 1114 97252394
medline 1 - 1114 97366845
medline 1 - 1114 97403937
medline 1 - 1114 97440308
medline 1 - 1114 98023959
medline 1 - 1114 98025012
medline 1 - 1114 98046016
medline 1 - 1114 98060982
medline 1 - 1114 98112443
medline 1 - 1114 98112456
medline 1 - 1114 98163458
medline 1 - 1114 98165568
medline 1 - 1114 98284533
medline 1 - 1114 98339719
medline 1 - 1114 98430996
medline 1 - 1114 99192369
medline 1 - 1114 99254982
medline 1 - 1114 99367902
medline 1 - 1114 99415738
medline 1 - 1114 99450824
mim 1 - 1114 114500
mim 1 - 1114 142623
mim 1 - 1114 155240
mim 1 - 1114 162300
mim 1 - 1114 164761
mim 1 - 1114 171300
mim 1 - 1114 171400
mim 1 - 1114 188550
mim 1 - 1114 191830
mim 1 - 1114 209880
mint 1 - 1114 MINT-265342
nextbio 1 - 1114 23271
oma 1 - 1114 GCARVYF
orphanet 1 - 1114 1332
orphanet 1 - 1114 146
orphanet 1 - 1114 388
orphanet 1 - 1114 653
orphanet 1 - 1114 661
orphanet 1 - 1114 93108
orphanet 1 - 1114 93172
orphanet 1 - 1114 93173
orthodb 1 - 1114 EOG9GTP0B
panther 1 - 1114 PTHR23256
panther 1 - 1114 PTHR23256:SF245
pathway_interaction_db 1 - 1114 ret_pathway
pdb 1 - 1114 1XPD
pdb 1 - 1114 2IVS
pdb 1 - 1114 2IVT
pdb 1 - 1114 2IVU
pdb 1 - 1114 2IVV
pdb 1 - 1114 2X2K
pdb 1 - 1114 2X2L
pdb 1 - 1114 2X2M
pdb 1 - 1114 2X2U
pdbsum 1 - 1114 1XPD
pdbsum 1 - 1114 2IVS
pdbsum 1 - 1114 2IVT
pdbsum 1 - 1114 2IVU
pdbsum 1 - 1114 2IVV
pdbsum 1 - 1114 2X2K
pdbsum 1 - 1114 2X2L
pdbsum 1 - 1114 2X2M
pdbsum 1 - 1114 2X2U
pfam 1 - 1114 PF00028
pfam 1 - 1114 PF07714
pharmgkb 1 - 1114 PA34335
phosphosite 1 - 1114 P07949
phylomedb 1 - 1114 P07949
pir 1 - 1114 A27203
pir 1 - 1114 A34630
pir 1 - 1114 B34735
pir 1 - 1114 S05582
pirsf 1 - 1114 PIRSF000631
pride 1 - 1114 P07949
prosite 1 - 1114 PS00107
prosite 1 - 1114 PS00109
prosite 1 - 1114 PS50011
prosite 1 - 1114 PS50268
proteinmodelportal 1 - 1114 P07949
pubmed 1 - 1114 10090908
pubmed 1 - 1114 10323403
pubmed 1 - 1114 10439047
pubmed 1 - 1114 10484767
pubmed 1 - 1114 10522989
pubmed 1 - 1114 10612852
pubmed 1 - 1114 10618407
pubmed 1 - 1114 10826520
pubmed 1 - 1114 10980597
pubmed 1 - 1114 11061555
pubmed 1 - 1114 11692159
pubmed 1 - 1114 12000816
pubmed 1 - 1114 12086152
pubmed 1 - 1114 12787916
pubmed 1 - 1114 14566559
pubmed 1 - 1114 14711813
pubmed 1 - 1114 16928683
pubmed 1 - 1114 16959974
pubmed 1 - 1114 17344846
pubmed 1 - 1114 18252215
pubmed 1 - 1114 19369195
pubmed 1 - 1114 2406025
pubmed 1 - 1114 2660074
pubmed 1 - 1114 2734021
pubmed 1 - 1114 3037315
pubmed 1 - 1114 3078962
pubmed 1 - 1114 7581377
pubmed 1 - 1114 7633441
pubmed 1 - 1114 7704557
pubmed 1 - 1114 7784092
pubmed 1 - 1114 7845675
pubmed 1 - 1114 7849720
pubmed 1 - 1114 7860065
pubmed 1 - 1114 7874109
pubmed 1 - 1114 7881414
pubmed 1 - 1114 7906417
pubmed 1 - 1114 7906866
pubmed 1 - 1114 7911697
pubmed 1 - 1114 7915165
pubmed 1 - 1114 8099202
pubmed 1 - 1114 8103403
pubmed 1 - 1114 8114938
pubmed 1 - 1114 8114939
pubmed 1 - 1114 8557249
pubmed 1 - 1114 8595427
pubmed 1 - 1114 8625130
pubmed 1 - 1114 8626834
pubmed 1 - 1114 8807338
pubmed 1 - 1114 9043870
pubmed 1 - 1114 9067749
pubmed 1 - 1114 9090527
pubmed 1 - 1114 9094028
pubmed 1 - 1114 9097963
pubmed 1 - 1114 9223675
pubmed 1 - 1114 9259198
pubmed 1 - 1114 9294615
pubmed 1 - 1114 9359036
pubmed 1 - 1114 9360560
pubmed 1 - 1114 9384613
pubmed 1 - 1114 9398735
pubmed 1 - 1114 9452064
pubmed 1 - 1114 9452077
pubmed 1 - 1114 9497256
pubmed 1 - 1114 9506724
pubmed 1 - 1114 9621513
pubmed 1 - 1114 9677065
pubmed 1 - 1114 9760196
refseq 1 - 1114 NP_065681.1
refseq 1 - 1114 NP_066124.1
smart 1 - 1114 SM00112
smart 1 - 1114 SM00219
string 1 - 1114 P07949
supfam 1 - 1114 SSF49313
supfam 1 - 1114 SSF56112
ucsc 1 - 1114 uc001jal.1
unigene 1 - 1114 Hs.350321
alt_init; mrna 1 - 1114 AAA36524.1
alt_init; mrna 1 - 1114 CAA33787.1
alt_init; mrna 1 - 1114 CAC14882.1
alt_seq; mrna 1 - 1114 AAA36786.1
act_site 874 - 874 Proton acceptor (By similarity)
binding 758 - 758 ATP (By similarity)
carbohyd 98 - 98 N-linked (GlcNAc...) (Potential)
carbohyd 151 - 151 N-linked (GlcNAc...) (Potential)
carbohyd 199 - 199 N-linked (GlcNAc...) (Potential)
carbohyd 336 - 336 N-linked (GlcNAc...) (Potential)
carbohyd 343 - 343 N-linked (GlcNAc...) (Potential)
carbohyd 361 - 361 N-linked (GlcNAc...) (Potential)
carbohyd 367 - 367 N-linked (GlcNAc...) (Potential)
carbohyd 377 - 377 N-linked (GlcNAc...) (Potential)
carbohyd 394 - 394 N-linked (GlcNAc...) (Potential)
carbohyd 448 - 448 N-linked (GlcNAc...) (Potential)
carbohyd 468 - 468 N-linked (GlcNAc...) (Potential)
carbohyd 554 - 554 N-linked (GlcNAc...) (Potential)
chain 29 - 1114 Proto-oncogene tyrosine-protein kinase receptor Ret. /FTId=PRO_0000024450.
conflict 647 - 647 I -> V (in Ref. 3; AAA36786)
conflict 750 - 750 A -> G (in Ref. 6; AAA36524)
conflict 904 - 904 S -> P (in Ref. 3; AAA36786)
domain 168 - 272 Cadherin
domain 724 - 1016 Protein kinase
Modification 696 - 696 Phosphoserine
Modification 806 - 806 Phosphotyrosine; by autocatalysis
Modification 809 - 809 Phosphotyrosine; by autocatalysis
Modification 900 - 900 Phosphotyrosine; by autocatalysis
Modification 905 - 905 Phosphotyrosine; by autocatalysis
Modification 981 - 981 Phosphotyrosine; by autocatalysis
Modification 1015 - 1015 Phosphotyrosine; by autocatalysis
Modification 1062 - 1062 Phosphotyrosine; by autocatalysis
Modification 1090 - 1090 Phosphotyrosine; by autocatalysis
Modification 1096 - 1096 Phosphotyrosine; by autocatalysis
np_bind 730 - 738 ATP (By similarity)
signal 1 - 28 Potential
site 712 - 713 Breakpoint for translocation to form PCM1-RET; RET-CCDC6; RET-GOLGA5; RET-TIF1 and RET-TRIM33 oncogenes.
topo_dom 29 - 635 Extracellular (Potential)
topo_dom 658 - 1114 Cytoplasmic (Potential)
transmem 636 - 657 Helical; (Potential)
variant 20 - 20 P -> L (in HSCR; sporadic form) /FTId=VAR_009459.
variant 32 - 32 S -> L (in HSCR; familial form) /FTId=VAR_006295.
variant 40 - 40 L -> P (in HSCR) /FTId=VAR_009492.
variant 64 - 64 P -> L (in HSCR; familial form) /FTId=VAR_006296.
variant 67 - 67 R -> H (in CCHS) /FTId=VAR_018153.
variant 77 - 77 R -> C (in HSCR) /FTId=VAR_009460.
variant 93 - 93 G -> S (in HSCR; could be a rare polymorphism). /FTId=VAR_006297.
variant 114 - 114 R -> H (in CCHS) /FTId=VAR_018154.
variant 142 - 142 C -> S (in HSCR; sporadic form) /FTId=VAR_006298.
variant 145 - 145 V -> G (in a colorectal cancer sample; somatic mutation). /FTId=VAR_035711.
variant 157 - 157 C -> Y (in HSCR; could be a polymorphism). /FTId=VAR_009461.
variant 163 - 163 R -> Q (in a colorectal adenocarcinoma sample; somatic mutation). /FTId=VAR_041762.
variant 174 - 174 F -> S (in HSCR; sporadic form) /FTId=VAR_009462.
variant 180 - 180 R -> P (in HSCR; sporadic form) /FTId=VAR_009463.
variant 197 - 197 C -> Y (in HSCR; sporadic form) /FTId=VAR_009464.
variant 198 - 198 P -> T (in renal adysplasia; prevents phosphorylation in response to GDNF). /FTId=VAR_044392.
variant 231 - 231 R -> H (in HSCR; familial form) /FTId=VAR_006299.
variant 251 - 251 E -> K (in HSCR; familial form) /FTId=VAR_006300.
variant 278 - 278 T -> N (in dbSNP:rs35118262) /FTId=VAR_041763.
variant 287 - 287 R -> Q (in HSCR; sporadic form) /FTId=VAR_006301.
variant 292 - 292 V -> M (in dbSNP:rs34682185) /FTId=VAR_041764.
variant 313 - 313 R -> Q (in HSCR; sporadic form) /FTId=VAR_009465.
variant 330 - 330 R -> Q (in HSCR) /FTId=VAR_006302.
variant 359 - 359 N -> K (in HSCR; could be a polymorphism). /FTId=VAR_009466.
variant 360 - 360 R -> W (in HSCR) /FTId=VAR_009467.
variant 376 - 376 V -> A (in renal adysplasia; constitutively phosphorylated; expressed only the immature intracellular form). /FTId=VAR_044393.
variant 393 - 393 F -> L (in HSCR; familial form) /FTId=VAR_006303.
variant 394 - 394 N -> H (in renal adysplasia; prevents phosphorylation in response to GDNF). /FTId=VAR_044394.
variant 394 - 394 N -> K (in HSCR) /FTId=VAR_009468.
variant 399 - 399 P -> L (in HSCR; sporadic form) /FTId=VAR_006304.
variant 432 - 432 A -> E (in CCHS) /FTId=VAR_018155.
variant 475 - 475 R -> Q (in HSCR; sporadic form) /FTId=VAR_006305.
variant 489 - 489 D -> N (in dbSNP:rs9282834) /FTId=VAR_018156.
variant 531 - 531 C -> CEEC (in MTC; familial form) /FTId=VAR_009469.
variant 593 - 593 G -> E (in a colorectal cancer sample; somatic mutation). /FTId=VAR_035712.
variant 600 - 600 R -> Q (probably a rare polymorphism) /FTId=VAR_008966.
variant 609 - 609 C -> G (in MEN2A) /FTId=VAR_009470.
variant 609 - 609 C -> R (in MEN2A) /FTId=VAR_009471.
variant 609 - 609 C -> W (in HSCR; familial form) /FTId=VAR_006307.
variant 609 - 609 C -> Y (in MTC, MEN2A and HSCR; familial and sporadic forms). /FTId=VAR_006306.
variant 611 - 611 C -> G (in MTC; familial form) /FTId=VAR_009472.
variant 611 - 611 C -> R (in MEN2A) /FTId=VAR_009473.
variant 611 - 611 C -> S (in MEN2A) /FTId=VAR_009474.
variant 611 - 611 C -> W (in MEN2A and MTC; familial form) /FTId=VAR_006308.
variant 611 - 611 C -> Y (in MEN2A) /FTId=VAR_006309.
variant 618 - 618 C -> F (in MEN2A and MTC; familial form) /FTId=VAR_006312.
variant 618 - 618 C -> G (in MEN2A) /FTId=VAR_006310.
variant 618 - 618 C -> R (in MEN2A, MTC and HSCR) /FTId=VAR_006311.
variant 618 - 618 C -> S (in MEN2A, HSCR and MTC; familial and sporadic forms). /FTId=VAR_006313.
variant 618 - 618 C -> Y (in MEN2A and MTC; familial form) /FTId=VAR_006314.
variant 620 - 620 C -> F (in MEN2A and MTC; familial form) /FTId=VAR_006318.
variant 620 - 620 C -> G (in MEN2A and MTC; familial and sporadic forms). /FTId=VAR_006315.
variant 620 - 620 C -> R (in MEN2A, MTC and HSCR; familial and sporadic forms). /FTId=VAR_006316.
variant 620 - 620 C -> S (in MEN2A and MTC; familial form) /FTId=VAR_006317.
variant 620 - 620 C -> W (in MEN2A and HSCR) /FTId=VAR_009475.
variant 620 - 620 C -> Y (in MEN2A) /FTId=VAR_006319.
variant 626 - 626 Q -> K (in HSCR; sporadic form) /FTId=VAR_009476.
variant 630 - 630 C -> F (in MEN2A and MTC; familial form) /FTId=VAR_006320.
variant 630 - 630 C -> S (in MTC; sporadic form) /FTId=VAR_009477.
variant 630 - 630 C -> Y (in MTC; familial and sporadic forms). /FTId=VAR_009478.
variant 631 - 631 D -> G (in thyroid carcinoma; somatic mutation). /FTId=VAR_006321.
variant 632 - 634 ELC -> DVR (in MEN2A) /FTId=VAR_006322.
variant 634 - 634 C -> CHELC (in MEN2A) /FTId=VAR_009479.
variant 634 - 634 C -> F (in MEN2A and pheochromocytoma) /FTId=VAR_006324.
variant 634 - 634 C -> G (in MEN2A and pheochromocytoma) /FTId=VAR_006323.
variant 634 - 634 C -> R (in MEN2A, pheochromocytoma and MTC; familial form; also found as somatic mutation in a sporadic thyroid carcinoma). /FTId=VAR_006326.
variant 634 - 634 C -> S (in MEN2A, pheochromocytoma and MTC; familial form). /FTId=VAR_006327.
variant 634 - 634 C -> W (in MEN2A, pheochromocytoma and MTC; familial form). /FTId=VAR_006328.
variant 634 - 634 C -> Y (in MEN2A, pheochromocytoma and MTC; familial form). /FTId=VAR_006325.
variant 634 - 635 CR -> WG (in MEN2A) /FTId=VAR_006329.
variant 636 - 636 T -> TCRT (in MEN2A) /FTId=VAR_006330.
variant 639 - 639 A -> G (in MTC; sporadic form) /FTId=VAR_012743.
variant 640 - 640 A -> G (in MEN2A) /FTId=VAR_009480.
variant 641 - 641 A -> G (in MTC; sporadic form) /FTId=VAR_012744.
variant 690 - 690 S -> P (in HSCR; sporadic form) /FTId=VAR_006331.
variant 691 - 691 G -> S (in dbSNP:rs1799939) /FTId=VAR_006332.
variant 749 - 749 R -> T (in dbSNP:rs34288963) /FTId=VAR_041765.
variant 762 - 762 E -> Q (in HSCR; sporadic form) /FTId=VAR_009481.
variant 765 - 765 S -> P (in HSCR) /FTId=VAR_009493.
variant 767 - 767 S -> R (in HSCR; sporadic form) /FTId=VAR_006334.
variant 768 - 768 E -> D (in MTC; familial and sporadic forms). /FTId=VAR_006335.
variant 778 - 778 V -> I (in renal adysplasia; constitutively phosphorylated). /FTId=VAR_044395.
variant 790 - 790 L -> F (in MEN2A and MTC; familial form) /FTId=VAR_009482.
variant 791 - 791 Y -> F (in HSCR, pheochromocytoma, MTC and MEN2A; familial form). /FTId=VAR_009483.
variant 804 - 804 V -> L (in MTC; familial form) /FTId=VAR_006336.
variant 804 - 804 V -> M (in MTC; familial form) /FTId=VAR_006337.
variant 813 - 813 R -> Q (in HSCR; sporadic form) /FTId=VAR_009484.
variant 826 - 826 Y -> S (in dbSNP:rs34617196) /FTId=VAR_041766.
variant 844 - 844 R -> L (in MTC; familial form; dbSNP:rs55947360). /FTId=VAR_011582.
variant 873 - 873 R -> Q (in HSCR; sporadic form) /FTId=VAR_006338.
variant 883 - 883 A -> F (in MEN2B; somatic mutation in sporadic medullary thyroid carcinoma; requires 2 nucleotide substitutions). /FTId=VAR_009485.
variant 891 - 891 S -> A (in MTC; familial form) /FTId=VAR_009486.
variant 893 - 893 F -> L (in HSCR; sporadic form) /FTId=VAR_006339.
variant 894 - 894 G -> S (in renal adysplasia; constitutively phosphorylated; expressed only the immature intracellular form). /FTId=VAR_044396.
variant 897 - 897 R -> Q (in HSCR; sporadic form) /FTId=VAR_006340.
variant 907 - 907 K -> E (in HSCR; sporadic form) /FTId=VAR_006341.
variant 918 - 918 M -> T (in renal adysplasia, MEN2B and MTC; sporadic form; somatic mutation). /FTId=VAR_006342.
variant 921 - 921 E -> K (in HSCR; sporadic form) /FTId=VAR_006343.
variant 922 - 922 S -> F (in MTC; sporadic form) /FTId=VAR_012745.
variant 922 - 922 S -> Y (rare polymorphism) /FTId=VAR_009487.
variant 946 - 946 T -> M (in MEN2B and MTC; familial form) /FTId=VAR_006345.
variant 972 - 972 R -> G (in HSCR; familial form) /FTId=VAR_006346.
variant 973 - 973 P -> L (in HSCR; familial form) /FTId=VAR_006347.
variant 980 - 980 M -> T (in HSCR; sporadic form) /FTId=VAR_006348.
variant 982 - 982 R -> C (in dbSNP:rs17158558) /FTId=VAR_006349.
variant 1039 - 1039 P -> L (in CCHS; with colonic aganglionosis). /FTId=VAR_018157.
variant 1039 - 1039 P -> Q /FTId=VAR_009488.
variant 1049 - 1049 P -> L (in renal adysplasia; prevents phosphorylation in response to GDNF). /FTId=VAR_044397.
variant 1059 - 1059 Missing (in HSCR) /FTId=VAR_009489.
variant 1061 - 1061 L -> P (in HSCR) /FTId=VAR_009490.
variant 1064 - 1064 M -> T (in HSCR; familial form) /FTId=VAR_009491.
variant 1067 - 1067 P -> S (in renal adysplasia; prevents phosphorylation in response to GDNF). /FTId=VAR_044398.
variant 1112 - 1112 F -> Y (in a bladder transitional cell carcinoma sample; somatic mutation). /FTId=VAR_041767.
keyword 1 - 1114 3D-structure
keyword 1 - 1114 ATP-binding
keyword 1 - 1114 Chromosomal rearrangement
keyword 1 - 1114 Complete proteome
keyword 1 - 1114 Disease mutation
keyword 1 - 1114 Glycoprotein
keyword 1 - 1114 Hirschsprung disease
keyword 1 - 1114 Kinase
keyword 1 - 1114 Membrane
keyword 1 - 1114 Nucleotide-binding
keyword 1 - 1114 Phosphoprotein
keyword 1 - 1114 Polymorphism
keyword 1 - 1114 Proto-oncogene
keyword 1 - 1114 Signal
keyword 1 - 1114 Transferase
keyword 1 - 1114 Transmembrane
keyword 1 - 1114 Transmembrane helix
keyword 1 - 1114 Tyrosine-protein kinase
Molecular Weight 1 - 1114 124319
1 hit 1 - 1114 PF00028
1 hit 1 - 1114 PF07714
1 hit 1 - 1114 PS00107
1 hit 1 - 1114 PS00109
1 hit 1 - 1114 PS50011
1 hit 1 - 1114 PS50268

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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