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REN / Renin 1

Renin

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.

Gene Name: Renin
Family/Subfamily: Protease , Aspartic A1
Synonyms: REN, Angiotensin-forming enzyme, Angiotensinogenase, HNFJ2, RENAA, Renin precursor, renal, Renin
Target Sequences: NM_000537 NP_000528.1 P00797

Publications (3)

1
Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation. Imre J Pavo, Noemi Pavo, Nina Kastner, Denise Traxler, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Martin Riesenhuber, David Lorant, Philipp E Bartko, Georg Goliasch, Martin Hülsmann, Johannes Winkler, Mariann Gyöngyösi. JACC. Basic to translational science. 2020 July;5:715-726. [Full Text Article] [PubMed:32760858] [PMC:PMC7393434]
2
Full Issue PDF. No authors listed. JACC. Basic to translational science. 2020 July;5:I-CX. [Full Text Article] [PubMed:32835137] [PMC:PMC7384789]
3
Comparison of the expression of neurotransmitter and muscular genesis markers in the postnatal male mouse masseter and trigeminal ganglion during development. Hiroaki Kamata, Hiroyuki Karibe, Iwao Sato. Journal of neuroscience research. 2018 June;96:1043-1055. [Full Text Article] [PubMed:29265492]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).