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Unfortunately, the antibody (ID:151889) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



RELA / NFKB p65

v-rel avian reticuloendotheliosis viral oncogene homolog A

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.

Gene Name: v-rel avian reticuloendotheliosis viral oncogene homolog A
Synonyms: RELA, NF-kappa-B p65delta3, NFKB3, p65, Transcription factor p65
Target Sequences: NM_021975 NP_068810.3 Q04206

Publications (17)

1
Dexamethasone attenuates NF-kappa B DNA binding activity without inducing I kappa B levels in rat brain in vivo. Unlap MT, Jope RS. Brain research. Molecular brain research. 1997 45:83-9. [PubMed:9105673] Related Antibodies: LS-B653.
2
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB. Journal of immunology (Baltimore, Md. : 1950). 1999 163:3474-83. [PubMed:10477620] Related Antibodies: LS-B653.
3
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB. Journal of immunology (Baltimore, Md. : 1950). 2002 169:6490-7. [PubMed:12444159] Related Antibodies: LS-B652, LS-C154220.
4
Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype. Poser I, Golob M, Buettner R, Bosserhoff AK. Molecular and cellular biology. 2003 23:2991-8. [PubMed:12665595] [PMC:PMC152547] Related Antibodies: LS-B653.
5
Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex. Starkey JM, Haidacher SJ, LeJeune WS, Zhang X, Tieu BC, Choudhary S, Brasier AR, Denner LA, Tilton RG. Diabetes. 2006 55:1252-9. [PubMed:16644679] Related Antibodies: LS-C18905.
6
NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. Cao S, Zhang X, Edwards JP, Mosser DM. The Journal of biological chemistry. 2006 281:26041-50. [PubMed:16835236] [PMC:PMC2642587] Related Antibodies: LS-B653.
7
Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. Khoury J, Ibla JC, Neish AS, Colgan SP. The Journal of clinical investigation. 2007 117:703-11. [PubMed:17318263] [PMC:PMC1797604] Related Antibodies: LS-C18905.
8
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. Lou H, Kaplowitz N. The Journal of biological chemistry. 2007 282:29470-81. [PubMed:17690092] Related Antibodies: LS-B653.
9
The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-kappaB pathway. Zhao L, Lee JY, Hwang DH. Biochemical pharmacology. 2008 75:1515-25. [PubMed:18243161] Related Antibodies: LS-B652.
10
CXCL5 promotes prostate cancer progression. Begley LA, Kasina S, Mehra R, Adsule S, Admon AJ, Lonigro RJ, Chinnaiyan AM, Macoska JA. Neoplasia (New York, N.Y.). 2008 10:244-54. [PubMed:18320069] [PMC:PMC2262133] Related Antibodies: LS-B653.
11
Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype. Yoon C, Korade Z, Carter BD. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:3738-46. [PubMed:18385332] Related Antibodies: LS-B653.
12
Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. Liu Q, Li J, Khoury J, Colgan SP, Ibla JC. The Journal of biological chemistry. 2009 284:13686-95. [PubMed:19297320] [PMC:PMC2679470] Related Antibodies: LS-C18905.
13
Role of NF-kappaB in flow-induced vascular remodeling. Castier Y, Ramkhelawon B, Riou S, Tedgui A, Lehoux S. Antioxidants & redox signaling. 2009 11:1641-9. [PubMed:19320561] Related Antibodies: LS-B652.
14
Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. Merkhofer EC, Cogswell P, Baldwin AS. Oncogene. 2010 29:1238-48. [PubMed:19946332] [PMC:PMC2829103] Related Antibodies: LS-C153771.
15
Axonal neuregulin 1 type III activates NF-kappaB in Schwann cells during myelin formation. Limpert AS, Carter BD. The Journal of biological chemistry. 2010 285:16614-22. [PubMed:20360002] [PMC:PMC2878070] Related Antibodies: LS-B653.
16
Nuclear factor-B contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes. Ghosh M, Yang Y, Rothstein JD, Robinson MB. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:9159-69. [PubMed:21697367] [PMC:PMC3138498] Related Antibodies: LS-B653.
17
Anti-inflammatory and anti-catabolic effects of TENDOACTIVE on human tenocytes in vitro. Shakibaei M, Buhrmann C, Mobasheri A. Histology and histopathology. 2011 26:1173-85. [PubMed:21751149] Related Antibodies: LS-B652.
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Filtered By: None
Target
rela-nfkb-p65 (341)
Reactivity
Human (336)
Mouse (195)
Rat (157)
Bat (14)
Bovine (50)
Chicken (5)
Chimpanzee (15)
Dog (32)
Drosophila (6)
Gibbon (6)
Guinea pig (12)
Hamster (14)
Horse (27)
Monkey (42)
Orangutan (3)
Pig (50)
Primate (10)
Rabbit (15)
Sheep (2)
Xenopus (14)
Zebrafish (4)
Application
IHC (88)
IHC-Fr (2)
IHC-P (85)
WB (291)
Flo (10)
ChrIP (5)
DB (18)
ELISA (164)
GS (7)
ICC (30)
IF (51)
IP (64)
PLA (3)
Host
rabbit (300)
mouse (32)
goat (1)
rat (1)
sheep (7)
Isotype
IgG (190)
IgG1 (6)
IgG1,k (3)
IgG1,l (1)
IgG2a (8)
IgG3 (7)
Clonality
monoclonal mc (35)
polyclonal pc (306)
Clone
112A1021 (2)
12K142 (1)
27F9.G4 (1)
2A12A7 (1)
340C1a (2)
5G6 (1)
6H7 (1)
8G3 (1)
Format
AF488 Conjugated (1)
AP Conjugated (12)
APC Conjugated (11)
Azide-free (4)
Biotin Conjugated (24)
DY488 Conjugated (2)
DY550 Conjugated (2)
DY650 Conjugated (2)
FITC Conjugated (20)
HRP Conjugated (18)
Magnetic beads Conjugated (1)
PE Conjugated (12)
Sepharose Conjugated (1)
Unconjugated (235)
Epitope
C-Terminus (31)
pSer536 (24)
pSer529 (13)
N-Terminus (12)
pSer276 (10)
pSer468 (10)
pSer311 (8)
pThr254 (8)
pThr505 (8)
Internal (6)
aa166-195 (6)
aa19-306 (6)
aa32-60 (6)
pThr435 (6)
aa516-542 (5)
aa21-70 (4)
aa269-318 (4)
pSer281 (4)
Acetyl-Lys310 (3)
aa470-550 (3)
aa501-551 (3)
aa526-539 (3)
Acetyl-Lys122 (2)
Acetyl-Lys218 (2)
Acetyl-Lys221 (2)
Leu523 (2)
Ser536 (2)
aa99-551 (2)
Acetyl-Lys314 (1)
Ala499 (1)
Gly530 (1)
Lys122 (1)
Lys218 (1)
Lys303 (1)
Lys310 (1)
Lys314 (1)
Met270 (1)
Mono-Methyl-Lys314/315 (1)
Ser276 (1)
Ser468 (1)
Ser529 (1)
Thr305 (1)
Thr429 (1)
Val248 (1)
Val462 (1)
aa1-254 (1)
aa1-50 (1)
aa100-170 (1)
aa12-317 (1)
aa129-144 (1)
aa136-224 (1)
aa143-158 (1)
aa190-270 (1)
aa2-17 (1)
aa210-290 (1)
aa220-300 (1)
aa221-270 (1)
aa225-274 (1)
aa247-296 (1)
aa249-298 (1)
aa250-330 (1)
aa275-324 (1)
aa278-327 (1)
aa291-479 (1)
aa297-308 (1)
aa370-450 (1)
aa402-451 (1)
aa410-490 (1)
aa435-484 (1)
aa440-520 (1)
aa456-551 (1)
aa471-520 (1)
aa496-545 (1)
aa503-507 (1)
aa538-546 (1)
aa539-551 (1)
Publications
No (336)
Yes (5)
Showing 1-25 out of 341 results
Anti-RELA / NFKB p65 Antibody (phospho-Ser529) IHC-plus™ LS-B652

Rabbit Polyclonal to Human RELA / NFKB p65
Rabbit, Pig, Horse, Human, Monkey
ELISA IHC-P IP WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (C-Terminus) IHC-plus™ LS-B653

Rabbit Polyclonal to Human RELA / NFKB p65
Mouse, Rat, Human
ELISA GS IF IHC-P IP WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (Ser536) IHC-plus™ LS-B1488

Rabbit Polyclonal (IgG) to Human RELA / NFKB p65
Mouse, Rat, Human
IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody IHC-plus™ LS-B53

Rabbit Polyclonal to Human RELA / NFKB p65
Human
ELISA IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (C-Terminus, clone 27F9.G4) LS-C153771

Mouse Monoclonal [clone 27F9.G4] (IgG) to Human RELA / NFKB p65
Human
ELISA IF IHC WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (N-Terminus) LS-C18905

Rabbit Polyclonal to Human RELA / NFKB p65
Human
ELISA IF IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (phospho-Ser276) LS-C154220

Rabbit Polyclonal (IgG) to Human RELA / NFKB p65
Human
ELISA WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (Acetyl-Lys122) LS-C387648

Rabbit Polyclonal (IgG) to Human RELA / NFKB p65
Mouse, Rat, Human
ELISA WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (clone 8G3) IHC-plus™ LS-B13554

Mouse Monoclonal [clone 8G3] (IgG1,l) to Human RELA / NFKB p65
Human
ELISA IF IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (C-Terminus) LS-C41295

Rabbit Polyclonal (IgG) to Mouse RELA / NFKB p65
Mouse, Rat, Human
WB
Unconjugated
Anti-RELA / NFKB p65 Antibody LS-C497795

Rabbit Monoclonal to Human RELA / NFKB p65
Human
Flo IF IHC IP WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (aa297-308) LS-C9296

Rabbit Polyclonal (IgG) to Human RELA / NFKB p65
Mouse, Dog, Bovine, Rat, Hamster, Horse, Bat, Human, Monkey
ELISA IF IHC WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (Acetyl-Lys310) LS-C354091

Rabbit Polyclonal to Human RELA / NFKB p65
Mouse, Bovine, Rat, Pig, Human
ChrIP ICC IF IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (phospho-Ser276) LS-C335799

Rabbit Polyclonal (IgG) to Human RELA / NFKB p65
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (Biotin) LS-C181888

Rabbit Polyclonal to Human RELA / NFKB p65
Mouse, Human, Primate
ICC IF IHC-P WB
Biotin Conjugated
Anti-RELA / NFKB p65 Antibody (aa275-324) IHC-plus™ LS-B12541

Rabbit Polyclonal (IgG) to Human RELA / NFKB p65
Mouse, Human
ELISA IF IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody IHC-plus™ LS-B6523

Rabbit Polyclonal to Human RELA / NFKB p65
Human
IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody LS-C48148

Rabbit Polyclonal to Mouse RELA / NFKB p65
Mouse, Rat, Human
IHC WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (aa143-158) LS-C312835

Rabbit Polyclonal to Human RELA / NFKB p65
Mouse, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Human, Monkey
ICC IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (phospho-Ser536) LS-C352793

Rabbit Polyclonal to Human RELA / NFKB p65
Mouse, Rat, Pig, Human, Monkey
IHC-P IP WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (phospho-Ser529) LS-C354093

Rabbit Polyclonal to Human RELA / NFKB p65
Mouse, Rat, Human, Monkey
IHC-P IP WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (aa136-224, clone 6H7) IHC-plus™ LS-B13961

Mouse Monoclonal [clone 6H7] (IgG1) to Human RELA / NFKB p65
Mouse, Human
ELISA IHC-P WB
Unconjugated
Anti-RELA / NFKB p65 Antibody (HRP) LS-C548348

Mouse Monoclonal (IgG3) to Human RELA / NFKB p65
Human
ELISA Flo ICC IF IHC WB
HRP Conjugated
Anti-RELA / NFKB p65 Antibody (Biotin) LS-C528247

Mouse Monoclonal (IgG3) to Human RELA / NFKB p65
Human
ELISA Flo ICC IF IHC WB
Biotin Conjugated
Anti-RELA / NFKB p65 Antibody (PE) LS-C656371

Mouse Monoclonal (IgG3) to Human RELA / NFKB p65
Human
ELISA Flo ICC IF IHC WB
PE Conjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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