REL / C-Rel

v-rel avian reticuloendotheliosis viral oncogene homolog

Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

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Proteins (2)

Type

Over-Expression Lysate (2)

Target

REL / C-Rel (2)

Publications

No (2)

Tag

Myc-DDK (Flag) (2)

Species

Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

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Human REL / C-Rel Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74881

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.5 kDa

Price:

20 µg/$215

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REL / C-Rel Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117668

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.5 kDa

Price:

100 µg/$710

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