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RDH12 / LCA3

retinol dehydrogenase 12 (all-trans/9-cis/11-cis)

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments.

Gene Name:	retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Synonyms:	RDH12, LCA13, LCA3, Retinol dehydrogenase 12, SDR7C2
Target Sequences:	Q96NR8 Q96NR8

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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