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RCHY1 / PIRH2

ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.

Gene Name:	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Synonyms:	RCHY1, ARNIP, CHIMP, HARNIP, HPirh2, PIRH2E, PIRH2, PIRH2F, PRO1996, RING finger protein 199, Zinc finger protein 363, ZNF363, p53-induced RING-H2 protein, RNF199
Target Sequences:	NP_056251.2 Q96PM5

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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