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RCC1
regulator of chromosome condensation 1
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
| Gene Name: | regulator of chromosome condensation 1 |
| Synonyms: | RCC1, Cell cycle regulatory protein, Chromosome condensation 1, RCC1-I, SNHG3-RCC1, CHC1 |
| Target Sequences: | NM_001269 NP_001260.1 P18754 |
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