RBX1 / ROC1

ring-box 1, E3 ubiquitin protein ligase

E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RBX1 / ROC1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human RBX1 / ROC1 Protein (Recombinant GST) (Full Length) - LS-G31884

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

37.62 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RBX1 / ROC1 Protein (Recombinant GST, N-terminus) (aa1-108) - LS-G56489

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human RBX1 / ROC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84229

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.1 kDa

Price:

20 µg/$150

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Human RBX1 / ROC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69268

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.1 kDa

Price:

20 µg/$1,107

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RBX1 / ROC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101179

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.1 kDa

Price:

100 µg/$494

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