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Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs), suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome.
Gene Name: | RNA-binding region (RNP1, RRM) containing 3 |
Synonyms: | RNPC3, KIAA1839, RBM40, RNA recognition protein, RNP, RNA-binding protein 40, U11/U12-65K, U11/U12 snRNP 65 kDa protein, RNA-binding motif protein 40, U11/U12 snRNP 65K |
Target Sequences: | AA807042 |
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