RBL1 / p107

retinoblastoma-like 1 (p107)

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

RBL1 / p107 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human RBL1 / p107 Protein (Recombinant GST, N-terminus) (aa905-1014) - LS-G59877

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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RBL1 / p107 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102539

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

114.5 kDa

Price:

100 µg/$494

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Human RBL1 / p107 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78628

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

114.5 kDa

Price:

20 µg/$150

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