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RBFOX1 / A2BP1

RNA binding protein, fox-1 homolog (C. elegans) 1

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: RNA binding protein, fox-1 homolog (C. elegans) 1
Synonyms: RBFOX1, A2BP1, 2BP1, Ataxin 2-binding protein 1, A2BP, FOX-1, FOX1, Ataxin-2-binding protein 1, Fox-1 homolog A, HRNBP1
Target Sequences: NM_018723 NP_061193.2 Q9NWB1

Publications (1)

1
Rbfox proteins regulate tissue-specific alternative splicing of Mef2D required for muscle differentiation. Runfola V, Sebastian S, Dilworth FJ, Gabellini D. Journal of cell science. 2015 128:631-7. (ICC; Mouse) [Full Text Article] [PubMed:25609712] [PMC:PMC4357529]

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Proteins (15)
Over-Expression Lysate (12)
Recombinant (3)
RBFOX1 / A2BP1 (15)
No (15)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (13)
Human (8)
Rat (1)
293T Cells (6)
E. coli (2)
HEK 293 Cells (7)
RBFOX1 / A2BP1 Protein - Purified recombinant protein RBFOX1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
42.6 kDa
20 µg/$1,107
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42.6 kDa
20 µg/$150
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42.6 kDa
20 µg/$150
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.8 kDa
20 µg/$150
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
44.6 kDa
20 µg/$215
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$150
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42.2 kDa
20 µg/$150
RBFOX1 / A2BP1 Protein - Recombinant Ataxin 2 Binding Protein 1 By SDS-PAGE
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E. coli
His-T7
30.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
42.6 kDa
100 µg/$494
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E. coli
His, N-Terminal
42.6 kDa
50 µg/$419
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.8 kDa
100 µg/$494
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.6 kDa
100 µg/$494
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
44.6 kDa
100 µg/$710
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.2 kDa
100 µg/$494
RBFOX1 / A2BP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).