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RBAK is a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus.
Gene Name: | RB-associated KRAB zinc finger |
Synonyms: | RBAK, HRBaK, RB-associated KRAB repressor, RB-associated KRAB zinc finger, Zinc finger protein 769, ZNF769 |
Target Sequences: | NM_021163 NP_066986.1 Q9NYW8 |
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