RASSF1 / RASSF1A

Ras association (RalGDS/AF-6) domain family member 1

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

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Products

Proteins (12)

Type

Over-Expression Lysate (9)

Recombinant (3)

Target

RASSF1 / RASSF1A (12)

Publications

No (12)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (9)

Species

Human (8)

Source

293T Cells (5)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (2)

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RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105620

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.7 kDa

Price:

100 µg/$494

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RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105622

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39 kDa

Price:

100 µg/$494

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RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105625

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31 kDa

Price:

100 µg/$494

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Human RASSF1 / RASSF1A Protein (Recombinant GST) (Full Length) - LS-G32551

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

55.33 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RASSF1 / RASSF1A Protein (Recombinant GST, N-terminus) (aa241-340) - LS-G61775

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80565

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.6 kDa

Price:

20 µg/$150

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Human RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80566

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.7 kDa

Price:

20 µg/$150

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Human RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80570

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39 kDa

Price:

20 µg/$150

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Human RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80571

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39 kDa

Price:

20 µg/$150

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Human RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80569

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31 kDa

Price:

20 µg/$150

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RASSF1 / RASSF1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100983

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.6 kDa

Price:

100 µg/$494

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Human RASSF1 / RASSF1A Protein (Recombinant His) - LS-G2033

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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