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RASSF1 / RASSF1A
Ras association (RalGDS/AF-6) domain family member 1
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
| Gene Name: | Ras association (RalGDS/AF-6) domain family member 1 |
| Synonyms: | RASSF1, 123F2, RASSF1A, RDA32, Tumor suppressor protein RDA32, NORE2A, WUGSC:H_LUCA12.5, REH3P21 |
| Target Sequences: | NM_007182 NP_009113.3 Q9NS23 |
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