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RASA4 / CAPRI
RAS p21 protein activator 4
RASA4 / CAPRI is a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | RAS p21 protein activator 4 |
| Synonyms: | RASA4, GAPL, KIAA0538, Ca2+-promoted Ras inactivator, CAPRI, RAS p21 protein activator 4 |
| Target Sequences: | NM_006989 NP_008920.5 O43374 |
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