RARRES2 / Chemerin

retinoic acid receptor responder (tazarotene induced) 2

Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.

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Products

Proteins (16)

Type

Over-Expression Lysate (2)

Recombinant (14)

Target

RARRES2 / Chemerin (16)

Publications

No (16)

Tag

6His, C-terminus (2)

GST (2)

GST, N-terminus (1)

His (3)

His-GST (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (12)

Mouse (2)

Rat (1)

Source

293T Cells (1)

E. coli (8)

HEK 293 Cells (2)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (3)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (4)

Biologically Active

Biologically active (2)

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Rat RARRES2 / Chemerin Protein (Recombinant His) (aa25-152) - LS-G13127

Source:

E. coli

Tag:

His

Molecular Weight:

16.1 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human RARRES2 / Chemerin Protein (Recombinant GST, N-terminus) (aa65-163) - LS-G59869

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RARRES2 / Chemerin Protein (Recombinant 6His, C-terminus) (Glu21-Ser157) - LS-G39983

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.9kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human RARRES2 / Chemerin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69747

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

15.5 kDa

Price:

20 µg/$1,107

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Human RARRES2 / Chemerin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85463

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.62 kDa

Price:

20 µg/$150

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Mouse RARRES2 / Chemerin Protein (Recombinant His-GST) (aa21-155) - LS-G13125

Source:

E. coli

Tag:

His-GST

Molecular Weight:

47.3 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Mouse RARRES2 / Chemerin Protein (Recombinant His-T7) (aa21-155) - LS-G13126

Source:

E. coli

Tag:

His-T7

Molecular Weight:

19.2 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human RARRES2 / Chemerin Protein (Recombinant His) (aa33-158) - LS-G13130

Source:

E. coli

Tag:

His

Molecular Weight:

16.1 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human RARRES2 / Chemerin Protein (Recombinant His-SUMO) (aa21-157) - LS-G21894

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

31.87 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human RARRES2 / Chemerin Protein (Recombinant GST) (Full Length) - LS-G30122

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

45 kDa

Price:

2 µg/$439

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Human RARRES2 / Chemerin Protein (Recombinant GST) (Full Length) - LS-G30123

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.8 kDa

Price:

2 µg/$439

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RARRES2 / Chemerin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99897

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.62 kDa

Price:

100 µg/$494

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Human RARRES2 / Chemerin Protein (Recombinant 6His, C-terminus) (Glu21-Ser157) - LS-G139691

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.9 kDa

Price:

10 µg/$288; 50 µg/$436

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Human RARRES2 / Chemerin Protein (Recombinant) - LS-G131417

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~16 kDa

Price:

25 µg/$395; 1 mg/$4,915

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Human RARRES2 / Chemerin Protein (Recombinant His) - LS-G2307

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human RARRES2 / Chemerin Protein (Recombinant) - LS-G327

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

15.6 kDa

Price:

5 µg/$268; 25 µg/$349

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