RARRES2 / Chemerin

retinoic acid receptor responder (tazarotene induced) 2

Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.

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Products

Antibodies (59)

ELISA Kits (29)

Proteins (16)

Type

Competitive EIA (1)

Custom (1)

Development Kit (2)

Over-Expression Lysate (2)

Primary (59)

Recombinant (14)

Sandwich (23)

Sandwich CLIA (2)

Target

RARRES2 / Chemerin (104)

Reactivity

Human (43)

Mouse (36)

Rat (19)

Bovine (1)

Pig (2)

Application

IHC (8)

IHC-P (6)

WB (52)

Flo (2)

ELISA (14)

IF (4)

Neut (1)

Host

rabbit (46)

mouse (10)

rat (3)

Product Group

DevKit DuoPlus (2)

IHCPlus (2)

Isotype

Ig (1)

IgG (10)

IgG2a (2)

IgG2b (2)

IgG2b,k (8)

Clonality

monoclonal mc (13)

polyclonal pc (46)

Clone

365317 (1)

Tigy-1 (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (8)

96-Well Strip Plate (17)

Antibody Pair and Standard (2)

APC (5)

APC Conjugated (5)

Biotin Conjugated (7)

Cy3 Conjugated (5)

Cy7 Conjugated (5)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (5)

Unconjugated (20)

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Epitope

aa33-158 (16)

aa21-155 (8)

aa25-152 (8)

aa21-157 (5)

aa17-156 (2)

C-Terminus (1)

Internal (1)

N-Terminus (1)

aa72-93 (1)

Publications

No (104)

Sample Type

Cell Culture Supernatants (9)

Cell Lysates (4)

Plasma (28)

Serum (28)

Tissue Homogenates (12)

Tag

6His, C-terminus (2)

GST (2)

GST, N-terminus (1)

His (3)

His-GST (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (12)

Mouse (2)

Rat (1)

Source

293T Cells (1)

E. coli (8)

HEK 293 Cells (2)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (3)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (4)

Biologically Active

Biologically active (2)

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RARRES2 / Chemerin Antibody LS-C335708

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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RARRES2 / Chemerin Antibody (aa33-158) LS-B13333

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (aa33-158) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$460

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Rat RARRES2 / Chemerin (Sandwich ELISA) ELISA Kit - LS-F6900

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$818

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IHC-plus™ RARRES2 / Chemerin Antibody (N-Terminus) LS-B16987

(4.0) Rating

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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RARRES2 / Chemerin Antibody LS-C35907

Antibody:

RARRES2 / Chemerin Rat anti-Mouse Monoclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, Neut, WB

Format:

Unconjugated

Price:

100 µg/$896

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RARRES2 / Chemerin Antibody (C-Terminus) LS-C352759

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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RARRES2 / Chemerin Antibody (aa25-152) LS-C293294

Antibody:

RARRES2 / Chemerin Rabbit anti-Rat Polyclonal (aa25-152) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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RARRES2 / Chemerin Antibody (aa21-157, clone 365317) LS-C35908

Antibody:

RARRES2 / Chemerin Mouse anti-Human Monoclonal (aa21-157) (365317) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$896

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RARRES2 / Chemerin Antibody (clone Tigy-1) LS-C343690

Antibody:

RARRES2 / Chemerin Mouse anti-Rat Monoclonal (Tigy-1) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$481

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RARRES2 / Chemerin Antibody (aa33-158, FITC) LS-C691702

Antibody:

RARRES2 / Chemerin Rabbit anti-Mouse Polyclonal (aa33-158) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$300; 200 µl/$338; 500 µl/$466; 1 ml/$530; 2 ml/$688; 5 ml/$1,149

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RARRES2 / Chemerin Antibody (aa72-93) LS-C143787

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (aa72-93) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA

Format:

Unconjugated

Price:

200 µg/$1,027

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RARRES2 / Chemerin Antibody (aa21-155, FITC) LS-C419757

Antibody:

RARRES2 / Chemerin Rabbit anti-Mouse Polyclonal (aa21-155) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$338; 200 µl/$392; 500 µl/$573; 1 ml/$698; 2 ml/$936; 5 ml/$1,588

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RARRES2 / Chemerin Antibody (APC) LS-C739248

Antibody:

RARRES2 / Chemerin Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$399; 200 µl/$479; 500 µl/$822; 1 ml/$978; 2 ml/$1,255; 5 ml/$2,353

Select

RARRES2 / Chemerin Antibody LS-C755212

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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RARRES2 / Chemerin Antibody (aa33-158, HRP) LS-C708714

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (aa33-158) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439

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Human RARRES2 / Chemerin (Sandwich ELISA) ELISA Kit - LS-F20979

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Rat RARRES2 / Chemerin Protein (Recombinant His) (aa25-152) - LS-G13127

Source:

E. coli

Tag:

His

Molecular Weight:

16.1 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human RARRES2 / Chemerin (Sandwich ELISA) ELISA Kit - LS-F4641

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

Select

RARRES2 / Chemerin Antibody LS-C770183

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

RARRES2 / Chemerin Antibody (aa21-157) LS-C370705

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (aa21-157) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

RARRES2 / Chemerin Antibody (aa21-157, HRP) LS-C370713

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (aa21-157) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

RARRES2 / Chemerin Antibody (aa21-157, Biotin) LS-C370716

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (aa21-157) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

RARRES2 / Chemerin Antibody (aa21-157, FITC) LS-C370715

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (aa21-157) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

RARRES2 / Chemerin Antibody (Internal) LS-C757711

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

RARRES2 / Chemerin Antibody LS-C779003

Antibody:

RARRES2 / Chemerin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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