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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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RARG / RAR-Gamma
retinoic acid receptor, gamma
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
| Gene Name: | retinoic acid receptor, gamma |
| Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
| Synonyms: | RARG, NR1B3, RAR-gamma, Retinoic acid receptor gamma, RARC, RARgamma, Retinoic acid receptor, gamma |
| Target Sequences: | NM_000966 AAA52692.1 P13631 |
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